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Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects : --the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study.
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- Lind, Lars (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset
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- Andersson, Jessika (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset
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- Rönn, Monika (author)
- Akademiska Sjukhuset
- show more...
- Hulthe, Johannes (author)
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- (creator_code:org_t)
- 2007-11-15
- 2008
- English.
- In: Lipids. - : Wiley. - 0024-4201 .- 1558-9307. ; 43:2, s. 133-41
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The aim of the present study was to relate brachial artery intima-media thickness (IMT) and the grey scale median of the intima-media complex (IM-GSM) to traditional cardiovascular risk factors and markers of inflammation and oxidative stress. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population-based study of 1016 subjects aged 70, brachial artery IMT and IM-GSM, who were evaluated by ultrasound. Lipids, thirteen markers of inflammation and nine markers of oxidative stress were measured. The Framingham risk score was related to IMT (p < 0.0001), but not to the IM-GSM. In univariate analysis, HDL-cholesterol, serum triglycerides, fasting glucose, smoking, HOMA insulin resistance index and oxidized LDL levels were related to IMT. HDL and LDL-cholesterol, triglycerides, VCAM-1, e-selectin, leukocyte count, conjugated diens, baseline conjugated diens (BCD)-LDL, antibodies to oxLDL, the GSSG/GSH glutathione ratio and homocysteine were related to IM-GSM. In multiple regression models, HDL-cholesterol, fasting glucose and oxLDL levels were the independently related to IMT (p = 0.01-0.04), while serum triglycerides, BCD-LDL and the GSSG/GSH ratio were independently related to IM-GSM (p = 0.0001-0.004). In conclusion, in addition to traditional lipid variables, markers of oxidative stress were associated with both thickness and echogenicity of the brachial artery intima-media complex. Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
Keyword
- Lipids
- Ultra sound
- Artery
- Oxidation
- Intima-media
- MEDICINE
- MEDICIN
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- ref (subject category)
- art (subject category)
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- Holdfelt, Peter
- Hulthe, Johannes
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- Elmgren, Anders
- Zilmer, Kersti
- Zilmer, Mihkel
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- About the subject
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- NATURAL SCIENCES
- NATURAL SCIENCES
- and Computer and Inf ...
- Articles in the publication
- Lipids
- By the university
- Uppsala University
- Chalmers University of Technology
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