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Brachial artery int...
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Lind, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset
(author)
Brachial artery intima-media thickness and echogenicity in relation to lipids and markers of oxidative stress in elderly subjects : --the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) Study.
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2007-11-15
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Wiley,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-103761
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-103761URI
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https://doi.org/10.1007/s11745-007-3125-6DOI
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https://research.chalmers.se/publication/100676URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The aim of the present study was to relate brachial artery intima-media thickness (IMT) and the grey scale median of the intima-media complex (IM-GSM) to traditional cardiovascular risk factors and markers of inflammation and oxidative stress. In the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study, a population-based study of 1016 subjects aged 70, brachial artery IMT and IM-GSM, who were evaluated by ultrasound. Lipids, thirteen markers of inflammation and nine markers of oxidative stress were measured. The Framingham risk score was related to IMT (p < 0.0001), but not to the IM-GSM. In univariate analysis, HDL-cholesterol, serum triglycerides, fasting glucose, smoking, HOMA insulin resistance index and oxidized LDL levels were related to IMT. HDL and LDL-cholesterol, triglycerides, VCAM-1, e-selectin, leukocyte count, conjugated diens, baseline conjugated diens (BCD)-LDL, antibodies to oxLDL, the GSSG/GSH glutathione ratio and homocysteine were related to IM-GSM. In multiple regression models, HDL-cholesterol, fasting glucose and oxLDL levels were the independently related to IMT (p = 0.01-0.04), while serum triglycerides, BCD-LDL and the GSSG/GSH ratio were independently related to IM-GSM (p = 0.0001-0.004). In conclusion, in addition to traditional lipid variables, markers of oxidative stress were associated with both thickness and echogenicity of the brachial artery intima-media complex. Thus, both thickness and echogenicity of the brachial artery intima-media complex might be useful biomarkers in the future.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Andersson, JessikaUppsala universitet,Institutionen för medicinska vetenskaper,Akademiska Sjukhuset
(author)
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Rönn, MonikaAkademiska Sjukhuset
(author)
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Gustavsson, Tomas,1954Chalmers tekniska högskola,Chalmers University of Technology(Swepub:cth)gustav
(author)
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Holdfelt, PeterChalmers tekniska högskola,Chalmers University of Technology
(author)
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Hulthe, Johannes
(author)
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Elmgren, AndersAstraZeneca AB
(author)
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Zilmer, KerstiTartu Ülikool,University of Tartu
(author)
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Zilmer, MihkelTartu Ülikool,University of Tartu
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Lipids: Wiley43:2, s. 133-410024-42011558-9307
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