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Mitochondrial ATP s...
Mitochondrial ATP synthase--a possible target protein in the regulation of energy metabolism in vitro and in vivo
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- Berger, Karin (author)
- Lund University,Lunds universitet,Molekylär endokrinologi,Forskargrupper vid Lunds universitet,Molekylär nutrition,Signaltransduktionsforskning,Molecular Endocrinology,Lund University Research Groups,Molecular Nutrition,Insulin Signal Transduction
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Sivars, Ulf (author)
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- Sörhede Winzell, Maria (author)
- Lund University,Lunds universitet,Medicin, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Johansson, Peter (author)
- Lund University,Lunds universitet,Medicinska fakulteten,Faculty of Medicine
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- Hellman, Ulf (author)
- Uppsala universitet,Ludwiginstitutet för cancerforskning
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- Rippe, Catarina (author)
- Lund University,Lunds universitet,Cellulär biomekanik,Forskargrupper vid Lunds universitet,Cellular Biomechanics,Lund University Research Groups
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- Erlanson-Albertsson, Charlotte (author)
- Lund University,Lunds universitet,Aptitkontroll,Forskargrupper vid Lunds universitet,Appetite Regulation,Lund University Research Groups
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(creator_code:org_t)
- 2013-12-02
- 2002
- English.
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In: Nutritional neuroscience. - : Informa UK Limited. - 1028-415X .- 1476-8305. ; 5:3, s. 201-210
- Related links:
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Subject headings
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- The increasing prevalence of obesity in the Western world has stimulated an intense search for mechanisms regulating food intake and energy balance. A number of appetite-regulating peptides have been identified, their receptors cloned and the intracellular events characterized. One possible energy-dissipating mechanism is the mitochondrial uncoupling of ATP-synthesis from respiratory chain oxidation through uncoupling proteins, whereby energy derived from food could be dissipated as heat, instead of stored as ATP. The exact role of the uncoupling proteins in energy balance is, however, uncertain. We show here that mitochondrial F1F0-ATP synthase itself is a target protein for an anorectic peptide, enterostatin, demonstrated both after affinity purification of rat brain membranes and through a direct physical interaction between enterostatin and purified F1-ATP synthase. In insulinoma cells (INS-1) enterostatin was found to target F1F0-ATP synthase, causing an inhibition of ATP production, an increased thermogenesis and increased oxygen consumption. The experiments suggest a role of mitochondrial F1F0-ATP synthase in the suppressed insulin secretion induced by enterostatin. It could be speculated that this targeting mechanism is involved in the decreased energy efficiency following enterostatin treatment in rat.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- Animals
- Calorimetry
- Cattle
- Colipases/pharmacology
- Cross-Linking Reagents
- Energy Metabolism
- Insulin/secretion
- Insulinoma/metabolism
- Male
- Mitochondria/*enzymology
- Oxygen Consumption
- Pancreatic Neoplasms/metabolism
- Protein Precursors/pharmacology
- Proton-Translocating ATPases/*metabolism
- Rats
- Rats; Sprague-Dawley
- Tumor Cells; Cultured
- Ins-1
- Enterostatin
- Insulin
- Thermogenesis
- Uncoupling Protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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