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Frequent loss of SM...
Frequent loss of SMAD4/DPC4 protein in colorectal cancers
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Salovaara, R. (author)
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Roth, S. (author)
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Loukola, A. (author)
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Launonen, V. (author)
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Sistonen, P. (author)
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Avizienyte, E. (author)
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Kristo, P. (author)
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Järvinen, H. (author)
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- Souchelnytskyi, Serhiy (author)
- Karolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning
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Sarlomo-Rikala, M. (author)
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Aaltonen, L.A. (author)
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(creator_code:org_t)
- BMJ, 2002
- 2002
- English.
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In: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 51:1, s. 56-59
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http://www.ncbi.nlm....
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https://gut.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND AND AIMS: Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as well as in germlines of humans predisposed to colon tumours. PATIENTS AND METHODS: The involvement of SMAD4 in sporadic colorectal neoplasia was evaluated by immunohistochemistry in 53 unselected cases and 27 cases displaying microsatellite instability. RESULTS: SMAD4 expression was absent in 20 of 53 (38%) unselected colorectal carcinomas, and reduced in another 15 (28%) cases. However, 26 of 27 cancers displaying microsatellite instability and TGF-betaIIR mutations were positive for SMAD4 immunostaining. CONCLUSIONS: Loss of SMAD4 expression may play a more prominent role in colon cancer than anticipated based on genetic evidence, but not in mutator phenotype tumours.
Keyword
- Chromosomes; Human; Pair 18/*genetics
- Colorectal Neoplasms/chemistry/*genetics
- DNA Mutational Analysis
- DNA-Binding Proteins/analysis/*genetics
- Gene Deletion
- Genetic Markers
- Humans
- Immunohistochemistry/methods
- Loss of Heterozygosity
- Microsatellite Repeats
- Receptors; Transforming Growth Factor beta/genetics
- Smad4 Protein
- Trans-Activators/analysis/*genetics
Publication and Content Type
- ref (subject category)
- art (subject category)
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Gut
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- By the author/editor
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Salovaara, R.
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Roth, S.
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Loukola, A.
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Launonen, V.
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Sistonen, P.
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Avizienyte, E.
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show more...
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Kristo, P.
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Järvinen, H.
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Souchelnytskyi, ...
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Sarlomo-Rikala, ...
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Aaltonen, L.A.
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show less...
- Articles in the publication
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Gut
- By the university
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Uppsala University
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Karolinska Institutet