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Frequent loss of SM...
Frequent loss of SMAD4/DPC4 protein in colorectal cancers
- Article/chapterEnglish2002
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-10422
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10422URI
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https://doi.org/10.1136/gut.51.1.56DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:18437223URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND AND AIMS: Loss of DNA sequences from chromosome 18q21 is a major genetic change in colorectal tumorigenesis. Multiple genes have been identified in this area. One of these, DPC4 (deleted in pancreatic cancer 4, also known as SMAD4), is mutated in a minor subset of colorectal carcinomas as well as in germlines of humans predisposed to colon tumours. PATIENTS AND METHODS: The involvement of SMAD4 in sporadic colorectal neoplasia was evaluated by immunohistochemistry in 53 unselected cases and 27 cases displaying microsatellite instability. RESULTS: SMAD4 expression was absent in 20 of 53 (38%) unselected colorectal carcinomas, and reduced in another 15 (28%) cases. However, 26 of 27 cancers displaying microsatellite instability and TGF-betaIIR mutations were positive for SMAD4 immunostaining. CONCLUSIONS: Loss of SMAD4 expression may play a more prominent role in colon cancer than anticipated based on genetic evidence, but not in mutator phenotype tumours.
Subject headings and genre
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Chromosomes; Human; Pair 18/*genetics
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Colorectal Neoplasms/chemistry/*genetics
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DNA Mutational Analysis
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DNA-Binding Proteins/analysis/*genetics
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Gene Deletion
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Genetic Markers
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Humans
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Immunohistochemistry/methods
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Loss of Heterozygosity
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Microsatellite Repeats
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Receptors; Transforming Growth Factor beta/genetics
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Smad4 Protein
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Trans-Activators/analysis/*genetics
Added entries (persons, corporate bodies, meetings, titles ...)
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Roth, S.
(author)
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Loukola, A.
(author)
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Launonen, V.
(author)
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Sistonen, P.
(author)
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Avizienyte, E.
(author)
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Kristo, P.
(author)
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Järvinen, H.
(author)
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Souchelnytskyi, SerhiyKarolinska Institutet,Uppsala universitet,Ludwiginstitutet för cancerforskning(Swepub:uu)sergsouc
(author)
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Sarlomo-Rikala, M.
(author)
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Aaltonen, L.A.
(author)
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Uppsala universitetLudwiginstitutet för cancerforskning
(creator_code:org_t)
Related titles
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In:Gut: BMJ51:1, s. 56-590017-57491468-3288
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Salovaara, R.
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Roth, S.
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Loukola, A.
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Launonen, V.
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Sistonen, P.
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Avizienyte, E.
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Kristo, P.
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Järvinen, H.
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Souchelnytskyi, ...
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Sarlomo-Rikala, ...
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Aaltonen, L.A.
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Gut
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Uppsala University
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Karolinska Institutet