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Acute effects of Helicobacter pylori extracts on gastric mucosal blood flow in the mouse
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- Henriksnäs, Johanna (author)
- Uppsala universitet,Integrativ Fysiologi
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- Atuma, Christer (author)
- Uppsala universitet,Integrativ Fysiologi
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- Phillipson, Mia (author)
- Uppsala universitet,Integrativ Fysiologi
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- (creator_code:org_t)
- Baishideng Publishing Group Inc. 2009
- 2009
- English.
- In: World Journal of Gastroenterology. - : Baishideng Publishing Group Inc.. - 1007-9327 .- 2219-2840. ; 15:2, s. 219-225
- Journal article (peer-reviewed)
Abstract
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- AIM: To investigate the mechanisms underlying the reduction in gastric blood flow induced by a luminal water extract of Helicobacter pylori (HPE).METHODS: The stomachs of isoflurane-anesthetized mice were exteriorized, and the mucosal surface exposed. Blood flow was measured with the laser-Doppler technique, and systemic arterial blood pressure monitored. C57BL/6 mice were exposed to water extract produced from H pylori strain 88-23. To investigate the role of a nerve- or iNOS-mediated pathway, we used intraluminal lidocaine and iNOS-/- mice. Blood flow response to the endogenous nitric oxide synthase inhibitor asymmetric dimethyl arginine (ADMA) was also assessed.RESULTS: In wild-type mice, HPE decreased mucosal blood flow by approximately 30%. This reduction was abolished in iNOS-deficient mice, and by pre-treatment with lidocaine. Luminally applied ADMA resulted in reduction in blood flow similar to that observed in wild-type mice exposed to HPE.CONCLUSION: A H pylori water extract reduces gastric mucosal blood flow acutely through iNOS- and nerve-mediated pathways.
Keyword
- Gastric mucosal blood flow
- In vivo
- Laser-Doppler flowmetry
- Mice
- Helicobacter pylori
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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