Search: onr:"swepub:oai:DiVA.org:uu-104364" >
Gastroprotective an...
Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash
-
- Petersson, Joel (author)
- Uppsala universitet,Integrativ Fysiologi
-
- Carlström, Mattias (author)
- Karolinska Institutet,Uppsala universitet,Integrativ Fysiologi
-
- Schreiber, Olof (author)
- Uppsala universitet,Integrativ Fysiologi
-
show more...
-
- Phillipson, Mia (author)
- Uppsala universitet,Integrativ Fysiologi
-
- Christoffersson, Gustaf (author)
- Uppsala universitet,Integrativ Fysiologi
-
- Jägare, Annika (author)
- Uppsala universitet,Integrativ Fysiologi
-
- Roos, Stefan (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology
-
Jansson, Emmelie Å. (author)
-
- Persson, A. Erik G. (author)
- Uppsala universitet,Integrativ Fysiologi
-
- Lundberg, Jon O. (author)
- Karolinska Institutet
-
- Holm, Lena (author)
- Uppsala universitet,Integrativ Fysiologi
-
show less...
-
(creator_code:org_t)
-
- Elsevier BV, 2009
- 2009
- English.
-
In: Free Radical Biology & Medicine. - : Elsevier BV. - 0891-5849 .- 1873-4596. ; 46:8, s. 1068-1075
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
https://res.slu.se/i...
-
show less...
Abstract
Subject headings
Close
- Recently, it has been suggested that the supposedly inert nitrite anion is reduced in vivo to form bioactive nitric oxide with physiological and therapeutic implications in the gastrointestinal and cardiovascular systems. Intake of nitrate-rich food such as vegetables results in increased levels of circulating nitrite in a process suggested to involve nitrate-reducing bacteria in the oral cavity. Here we investigated the importance of the oral microflora and dietary nitrate in regulation of gastric mucosal defense and blood pressure. Rats were treated twice daily with a commercial antiseptic mouthwash while they were given nitrate-supplemented drinking water. The mouthwash greatly reduced the number of nitrate-reducing oral bacteria and as a consequence, nitrate-induced increases in gastric NO and circulating nitrite levels were markedly reduced. With the mouthwash the observed nitrate-induced increase in gastric mucus thickness was attenuated and the gastroprotective effect against an ulcerogenic compound was lost. Furthermore, the decrease in systemic blood pressure seen during nitrate supplementation was now absent. These results suggest that oral symbiotic bacteria modulate gastrointestinal and cardiovascular function via bioactivation of salivary nitrate. Excessive use of antiseptic mouthwashes may attenuate the bioactivity of dietary nitrate.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
Keyword
- Nitrate
- Nitrite
- Nitric Oxide
- Gastric Mucus
- Gastric Mucosal Damage
- Blood Pressure
- DASH
- Cardiovascular
- Atherosclcrosis
- Endothelial Dysfunction
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Petersson, Joel
-
Carlström, Matti ...
-
Schreiber, Olof
-
Phillipson, Mia
-
Christoffersson, ...
-
Jägare, Annika
-
show more...
-
Roos, Stefan
-
Jansson, Emmelie ...
-
Persson, A. Erik ...
-
Lundberg, Jon O.
-
Holm, Lena
-
show less...
- About the subject
-
- AGRICULTURAL SCIENCES
-
AGRICULTURAL SCI ...
-
and Agriculture Fore ...
-
and Food Science
- Articles in the publication
-
Free Radical Bio ...
- By the university
-
Uppsala University
-
Karolinska Institutet
-
Swedish University of Agricultural Sciences