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  • Petersson, JoelUppsala universitet,Integrativ Fysiologi (author)

Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • Elsevier BV,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-104364
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104364URI
  • https://doi.org/10.1016/j.freeradbiomed.2009.01.011DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:118612945URI
  • https://res.slu.se/id/publ/25592URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Recently, it has been suggested that the supposedly inert nitrite anion is reduced in vivo to form bioactive nitric oxide with physiological and therapeutic implications in the gastrointestinal and cardiovascular systems. Intake of nitrate-rich food such as vegetables results in increased levels of circulating nitrite in a process suggested to involve nitrate-reducing bacteria in the oral cavity. Here we investigated the importance of the oral microflora and dietary nitrate in regulation of gastric mucosal defense and blood pressure. Rats were treated twice daily with a commercial antiseptic mouthwash while they were given nitrate-supplemented drinking water. The mouthwash greatly reduced the number of nitrate-reducing oral bacteria and as a consequence, nitrate-induced increases in gastric NO and circulating nitrite levels were markedly reduced. With the mouthwash the observed nitrate-induced increase in gastric mucus thickness was attenuated and the gastroprotective effect against an ulcerogenic compound was lost. Furthermore, the decrease in systemic blood pressure seen during nitrate supplementation was now absent. These results suggest that oral symbiotic bacteria modulate gastrointestinal and cardiovascular function via bioactivation of salivary nitrate. Excessive use of antiseptic mouthwashes may attenuate the bioactivity of dietary nitrate.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carlström, MattiasKarolinska Institutet,Uppsala universitet,Integrativ Fysiologi(Swepub:uu)macar229 (author)
  • Schreiber, OlofUppsala universitet,Integrativ Fysiologi(Swepub:uu)olosc876 (author)
  • Phillipson, MiaUppsala universitet,Integrativ Fysiologi(Swepub:uu)mjo07958 (author)
  • Christoffersson, GustafUppsala universitet,Integrativ Fysiologi(Swepub:uu)guchr179 (author)
  • Jägare, AnnikaUppsala universitet,Integrativ Fysiologi(Swepub:uu)aja24796 (author)
  • Roos, StefanSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för mikrobiologi,Department of Microbiology(Swepub:slu)48983 (author)
  • Jansson, Emmelie Å. (author)
  • Persson, A. Erik G.Uppsala universitet,Integrativ Fysiologi(Swepub:uu)erikpers (author)
  • Lundberg, Jon O.Karolinska Institutet (author)
  • Holm, LenaUppsala universitet,Integrativ Fysiologi(Swepub:uu)pho23887 (author)
  • Uppsala universitetIntegrativ Fysiologi (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:Free Radical Biology & Medicine: Elsevier BV46:8, s. 1068-10750891-58491873-4596

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