Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition

Heldin, Carl-Henrik (author): Uppsala universitet,Ludwiginstitutet för cancerforskning

Landström, Maréne (author): Uppsala universitet,Ludwiginstitutet för cancerforskning,Institutionen för genetik och patologi,Ludwig Institute for Cancer Research, Uppsala University

Moustakas, Aristidis (author): Uppsala universitet,Ludwiginstitutet för cancerforskning

(creator_code:org_t)

Elsevier Ltd. 2009
2009
English.
In: Current Opinion in Cell Biology. - : Elsevier Ltd.. - 0955-0674 .- 1879-0410. ; 21:2, s. 166-176

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; https://urn.kb.se/re...; show less...

Abstract Subject headings

Members of the transforming growth factor-beta (TGF-beta) family have important roles during embryogenesis, as well as in the control of tissue homeostasis in the adult. They exert their cellular effects via binding to serine/threonine kinase receptors. Members of the Smad family of transcription factors are important intracellular messengers, and recent studies have shown that the ubiquitin ligase TRAF6 mediates other specific signals. TGF-beta signaling is tightly controlled by post-translational modifications, which regulate the activity, stability, and subcellular localization of the signaling components. The aim of this review is to summarize some of the recent findings on the mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition.

By the author/editor: Heldin, Carl-Hen ...; Landström, Marén ...; Moustakas, Arist ...

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