Search: onr:"swepub:oai:DiVA.org:uu-104497" >
Cardiovascular risk...
Cardiovascular risk and renal transplantation : post hoc analyses of the Assessment of Lescol in Renal Transplantation (ALERT) Study
-
Jardine, Alan G. (author)
-
- Fellström, Bengt, 1947- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,The ALERT study.
-
- Logan, John O. (author)
- The ALERT Study
-
show more...
-
- Cole, Edward (author)
- The ALERT Study
-
- Nyberg, Gudrun (author)
- The ALERT Study
-
- Grönhagen-Riska, Carola (author)
- The ALERT Study
-
- Madsen, Søren (author)
- The ALERT Study
-
- Neumayer, Hans-Hellmut (author)
- The ALERT Study
-
- Maes, Bart (author)
- The ALERT Study
-
- Ambühl, Patrice (author)
- The ALERT Study
-
- Olsson, Anders (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Internmedicin,Endokrin- och magtarmmedicinska kliniken US
-
- Pedersen, T. (author)
- The ALERT Study
-
- Holdaas, Hallvard (author)
- The ALERT Study
-
show less...
-
(creator_code:org_t)
- Elsevier BV, 2005
- 2005
- English.
-
In: American Journal of Kidney Diseases. - : Elsevier BV. - 0272-6386 .- 1523-6838. ; 46:3, s. 529-36
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Renal transplantation is associated with an increased risk for premature cardiovascular disease. We analyzed the data in the placebo arm of Assessment of Lescol in Renal Transplantation (ALERT) to improve our understanding of the relationship between cardiovascular risk factors and outcomes in this unique population. METHODS: We performed Cox survival analysis for myocardial infarction, cardiac death, and noncardiac death in 1,052 patients recruited to the placebo arm of ALERT. These subjects were aged 30 to 75 years, had stable graft function at least 6 months after transplantation, had a serum total cholesterol level between 155 and 348 mg/dL (4 and 9 mmol/L), and were receiving cyclosporine-based immunosuppression. RESULTS: The results confirm previous studies. In multivariate analysis, preexisting coronary heart disease (hazard ratio [HR], 3.69; P < 0.001), total cholesterol level (HR, 1.55 per 50 mg/dL; P = 0.0045), and prior acute rejection (HR, 2.36; P = 0.0023) were independent risk factors. Conversely, independent risk factors for cardiac death were age (HR, 1.58 per decade; P = 0.0033), diabetes (HR, 3.35; P = 0.0002), ST-T changes on the ECG (HR, 3.17; P = 0.0004), and serum creatinine level (HR, 2.65 per milligram per deciliter; P < 0.0001). CONCLUSION: This analysis confirms that renal transplant recipients share risk factors for myocardial infarction and cardiac death with the general population. However, the pattern of risk factors and their relationship with outcomes is atypical, highlighting the unique nature of cardiovascular risk in transplant recipients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Cardiovascular risk
- renal disease
- transplantation
- Kidney diseases
- Njursjukdomar
- Medicine
- medicin
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Jardine, Alan G.
-
Fellström, Bengt ...
-
Logan, John O.
-
Cole, Edward
-
Nyberg, Gudrun
-
Grönhagen-Riska, ...
-
show more...
-
Madsen, Søren
-
Neumayer, Hans-H ...
-
Maes, Bart
-
Ambühl, Patrice
-
Olsson, Anders
-
Pedersen, T.
-
Holdaas, Hallvar ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Urology and Neph ...
- Articles in the publication
-
American Journal ...
- By the university
-
Uppsala University
-
Linköping University