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Differential tissue-specific protein markers of vaginal carcinoma

Hellman, Kristina (author)
Karolinska Institutet
Alaiya, Ayodele A. (author)
Karolinska Institutet
Becker, Susanne (author)
Unit of Cancer Proteomics, Department of Oncology and Pathology, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden
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Lomnytska, Marta (author)
Karolinska Institutet
Schedvins, Kjell (author)
Department of Gynaecology, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Steinberg, Winfried (author)
Institution of Cytological Diagnosis (Kloster-Paradiese), Im Stiftsfeld, 159494 Soest, Germany
Hellström, Ann-Cathrin (author)
Department of Gynaecologic Oncology, Radiumhemmet, Karolinska University Hospital, SE-171 76 Stockholm, Sweden
Andersson, Sonia (author)
Karolinska Institutet
Hellman, Ulf (author)
Uppsala universitet,Ludwiginstitutet för cancerforskning
Auer, Gert (author)
Karolinska Institutet
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 (creator_code:org_t)
2009-03-24
2009
English.
In: British Journal of Cancer. - : Cancer Research UK. - 0007-0920 .- 1532-1827. ; 100:8, s. 1303-1314
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  • Research review (peer-reviewed)
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  • The objective was to identify proteins differentially expressed in vaginal cancer to elucidate relevant cancer-related proteins. A total of 16 fresh-frozen tissue biopsies, consisting of 5 biopsies from normal vaginal epithelium, 6 from primary vaginal carcinomas and 5 from primary cervical carcinomas, were analysed using two-dimensional gel electrophoresis (2-DE) and MALDI-TOF mass spectrometry. Of the 43 proteins identified with significant alterations in protein expression between non-tumourous and tumourous tissue, 26 were upregulated and 17 were downregulated. Some were similarly altered in vaginal and cervical carcinoma, including cytoskeletal proteins, tumour suppressor proteins, oncoproteins implicated in apoptosis and proteins in the ubiquitin-proteasome pathway. Three proteins were uniquely altered in vaginal carcinoma (DDX48, erbB3-binding protein and biliverdin reductase) and five in cervical carcinoma (peroxiredoxin 2, annexin A2, sarcomeric tropomyosin kappa, human ribonuclease inhibitor and prolyl-4-hydrolase beta). The identified proteins imply involvement of multiple different cellular pathways in the carcinogenesis of vaginal carcinoma. Similar protein alterations were found between vaginal and cervical carcinoma suggesting common tumourigenesis. However, the expression level of some of these proteins markedly differs among the three tissue specimens indicating that they might be useful molecular markers.

Keyword

vaginal carcinoma
cervical carcinoma
proteomics
MEDICINE
MEDICIN

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