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Enhancing the effec...
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Sundberg, Åsa LiljegrenUppsala universitet,Enheten för biomedicinsk strålningsvetenskap
(author)
Enhancing the effect of radionuclide tumor targeting, using lysosomotropic weak bases
- Article/chapterEnglish2007
Publisher, publication year, extent ...
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Elsevier BV,2007
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-104625
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-104625URI
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https://doi.org/10.1016/j.ijrobp.2006.07.1369DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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PURPOSE: The aim of the present study was to investigate if treatment with lysosomotropic weak bases could increase the intracellular retention of radiohalogens and thereby increase the therapeutic effect of radionuclide tumor targeting. METHODS AND MATERIALS: Four different lysosomotropic bases, chloroquine, ammonium chloride, amantadine, and thioridazine, were investigated for their ability to increase radiohalogen retention in vitro. The two most promising substances, chloroquine and ammonium chloride, were studied in several cell lines (A431, U343MGaCl2:6, SKOV-3, and SKBR-3) in combination with radiolabeled epidermal growth factor (EGF) or the HER2 binding affibody (Z(HER2:4))(2). RESULTS: The uptake and retention of radionuclides was found to be substantially increased by simultaneous treatment with the lysosomotropic bases. The effect was, however, more pronounced in the epidermal growth factor:epidermal growth factor receptor (EGF:EGFR) system than in the (Z(HER2:4))(2):HER2 system. The therapeutic effect of ammonium chloride treatment combined with (211)At-EGF was also studied. The effect obtained after combined treatment was found to be much better than after (211)At-EGF treatment alone. CONCLUSIONS: The encouraging results from the present study indicate that the use of lysosomotropic weak bases is a promising approach for increasing the therapeutic effect of radionuclide targeting with radiohalogens.
Subject headings and genre
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EGF
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HER2
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Lysosomotropic weak bases
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Radionuclide therapy
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Tumor targeting
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Steffen, Ann-CharlottUppsala universitet,Enheten för biomedicinsk strålningsvetenskap(Swepub:uu)anste677
(author)
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Uppsala universitetEnheten för biomedicinsk strålningsvetenskap
(creator_code:org_t)
Related titles
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In:International Journal of Radiation Oncology, Biology, Physics: Elsevier BV67:1, s. 279-2870360-30161879-355X
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