A common coding variant in CASP8 is associated with breast cancer risk

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Fältnamn	Indikatorer	Metadata
000		05622naa a2201261 4500
001		oai:DiVA.org:uu-105522
003		SwePub
008		090604s2007 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:12540830
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1055222 URI
024	7	a https://doi.org/10.1038/ng19812 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:125408302 URI
040		a (SwePub)uud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Cox, Angela4 aut
245	1 0	a A common coding variant in CASP8 is associated with breast cancer risk
264		c 2007-02-11
264	1	b Springer Science and Business Media LLC,c 2007
338		a print2 rdacarrier
520		a The Breast Cancer Association Consortium (BCAC) has been established to conduct combined case-control analyses with augmented statistical power to try to confirm putative genetic associations with breast cancer. We genotyped nine SNPs for which there was some prior evidence of an association with breast cancer: CASP8 D302H (rs1045485), IGFBP3 -202 C --> A (rs2854744), SOD2 V16A (rs1799725), TGFB1 L10P (rs1982073), ATM S49C (rs1800054), ADH1B 3' UTR A --> G (rs1042026), CDKN1A S31R (rs1801270), ICAM5 V301I (rs1056538) and NUMA1 A794G (rs3750913). We included data from 9-15 studies, comprising 11,391-18,290 cases and 14,753-22,670 controls. We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.: 0.62-0.87) for heterozygotes and rare homozygotes, respectively, compared with common homozygotes; P(trend) = 1.1 x 10(-7)) and weaker evidence for TGFB1 L10P (OR = 1.07 (95% c.i.: 1.02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies.
653		a MEDICINE
653		a MEDICIN
700	1	a Dunning, Alison M.4 aut
700	1	a Garcia-Closas, Montserrat4 aut
700	1	a Balasubramanian, Sabapathy4 aut
700	1	a Reed, Malcolm W. R.4 aut
700	1	a Pooley, Karen A.4 aut
700	1	a Scollen, Serenau Karolinska Institutet4 aut
700	1	a Baynes, Caroline4 aut
700	1	a Ponder, Bruce A. J.4 aut
700	1	a Chanock, Stephen4 aut
700	1	a Lissowska, Jolanta4 aut
700	1	a Brinton, Louise4 aut
700	1	a Peplonska, Beata4 aut
700	1	a Southey, Melissa C.4 aut
700	1	a Hopper, John L.4 aut
700	1	a McCredie, Margaret R. E.4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Fletcher, Olivia4 aut
700	1	a Johnson, Nichola4 aut
700	1	a dos Santos Silva, Isabel4 aut
700	1	a Gibson, Lorna4 aut
700	1	a Bojesen, Stig E.4 aut
700	1	a Nordestgaard, Børge G.4 aut
700	1	a Axelsson, Christen K.4 aut
700	1	a Torres, Diana4 aut
700	1	a Hamann, Ute4 aut
700	1	a Justenhoven, Christina4 aut
700	1	a Brauch, Hiltrud4 aut
700	1	a Chang-Claude, Jenny4 aut
700	1	a Kropp, Silke4 aut
700	1	a Risch, Angela4 aut
700	1	a Wang-Gohrke, Shan4 aut
700	1	a Schürmann, Peter4 aut
700	1	a Bogdanova, Natalia4 aut
700	1	a Dörk, Thilo4 aut
700	1	a Fagerholm, Rainer4 aut
700	1	a Aaltonen, Kirsimari4 aut
700	1	a Blomqvist, Carlu Uppsala universitet,Enheten för onkologi4 aut
700	1	a Nevanlinna, Heli4 aut
700	1	a Seal, Sheila4 aut
700	1	a Renwick, Anthony4 aut
700	1	a Stratton, Michael R.4 aut
700	1	a Rahman, Nazneen4 aut
700	1	a Sangrajrang, Suleeporn4 aut
700	1	a Hughes, David4 aut
700	1	a Odefrey, Fabrice4 aut
700	1	a Brennan, Paul4 aut
700	1	a Spurdle, Amanda B.4 aut
700	1	a Chenevix-Trench, Georgia4 aut
700	1	a Beesley, Jonathan4 aut
700	1	a Mannermaa, Arto4 aut
700	1	a Hartikainen, Jaana4 aut
700	1	a Kataja, Vesa4 aut
700	1	a Kosma, Veli-Matti4 aut
700	1	a Couch, Fergus J.4 aut
700	1	a Olson, Janet E.4 aut
700	1	a Goode, Ellen L.4 aut
700	1	a Broeks, Annegien4 aut
700	1	a Schmidt, Marjanka K.4 aut
700	1	a Hogervorst, Frans B. L.4 aut
700	1	a Van't Veer, Laura J.4 aut
700	1	a Kang, Daehee4 aut
700	1	a Yoo, Keun-Young4 aut
700	1	a Noh, Dong-Young4 aut
700	1	a Ahn, Sei-Hyun4 aut
700	1	a Wedrén, Sara4 aut
700	1	a Hall, Peru Karolinska Institutet4 aut
700	1	a Low, Yen-Ling4 aut
700	1	a Liu, Jianjun4 aut
700	1	a Milne, Roger L4 aut
700	1	a Ribas, Gloria4 aut
700	1	a Gonzalez-Neira, Anna4 aut
700	1	a Benitez, Javier4 aut
700	1	a Sigurdson, Alice J.4 aut
700	1	a Stredrick, Denise L.4 aut
700	1	a Alexander, Bruce H.4 aut
700	1	a Struewing, Jeffery P.4 aut
700	1	a Pharoah, Paul D. P.4 aut
700	1	a Easton, Douglas F.4 aut
710	2	a Karolinska Institutetb Enheten för onkologi4 org
773	0	t Nature Geneticsd : Springer Science and Business Media LLCg 39:3, s. 352-358q 39:3<352-358x 1061-4036x 1546-1718
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-105522
856	4 8	u https://doi.org/10.1038/ng1981
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:12540830

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By the author/editor: Cox, Angela; Dunning, Alison ...; Garcia-Closas, M ...; Balasubramanian, ...; Reed, Malcolm W. ...; Pooley, Karen A.; show more...; Scollen, Serena; Baynes, Caroline; Ponder, Bruce A. ...; Chanock, Stephen; Lissowska, Jolan ...; Brinton, Louise; Peplonska, Beata; Southey, Melissa ...; Hopper, John L.; McCredie, Margar ...; Giles, Graham G.; Fletcher, Olivia; Johnson, Nichola; dos Santos Silva ...; Gibson, Lorna; Bojesen, Stig E.; Nordestgaard, Bø ...; Axelsson, Christ ...; Torres, Diana; Hamann, Ute; Justenhoven, Chr ...; Brauch, Hiltrud; Chang-Claude, Je ...; Kropp, Silke; Risch, Angela; Wang-Gohrke, Sha ...; Schürmann, Peter; Bogdanova, Natal ...; Dörk, Thilo; Fagerholm, Raine ...; Aaltonen, Kirsim ...; Blomqvist, Carl; Nevanlinna, Heli; Seal, Sheila; Renwick, Anthony; Stratton, Michae ...; Rahman, Nazneen; Sangrajrang, Sul ...; Hughes, David; Odefrey, Fabrice; Brennan, Paul; Spurdle, Amanda ...; Chenevix-Trench, ...; Beesley, Jonatha ...; Mannermaa, Arto; Hartikainen, Jaa ...; Kataja, Vesa; Kosma, Veli-Matt ...; Couch, Fergus J.; Olson, Janet E.; Goode, Ellen L.; Broeks, Annegien; Schmidt, Marjank ...; Hogervorst, Fran ...; Van't Veer, Laur ...; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Wedrén, Sara; Hall, Per; Low, Yen-Ling; Liu, Jianjun; Milne, Roger L; Ribas, Gloria; Gonzalez-Neira, ...; Benitez, Javier; Sigurdson, Alice ...; Stredrick, Denis ...; Alexander, Bruce ...; Struewing, Jeffe ...; Pharoah, Paul D. ...; Easton, Douglas ...; show less...

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