Search: onr:"swepub:oai:DiVA.org:uu-106449" >
The legacy of domes...
The legacy of domestication : Accumulation of deleterious mutations in the dog genome
-
Cruz, F. (author)
-
- Vilà, C. (author)
- Uppsala universitet,Evolutionsbiologi
-
- Webster, Matthew T. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
(creator_code:org_t)
- 2008-08-21
- 2008
- English.
-
In: Molecular biology and evolution. - : Oxford University Press (OUP). - 0737-4038 .- 1537-1719. ; 25:11, s. 2331-2336
- Related links:
-
https://academic.oup...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Dogs exhibit more phenotypic variation than any other mammal and are affected by a wide variety of genetic diseases. However, the origin and genetic basis of this variation is still poorly understood. We examined the effect of domestication on the dog genome by comparison with its wild ancestor, the gray wolf. We compared variation in dog and wolf genes using whole-genome single nucleotide polymorphism (SNP) data. The d(N)/d(S) ratio (omega) was around 50% greater for SNPs found in dogs than in wolves, indicating that a higher proportion of nonsynonymous alleles segregate in dogs compared with nonfunctional genetic variation. We suggest that the majority of these alleles are slightly deleterious and that two main factors may have contributed to their increase. The first is a relaxation of selective constraint due to a population bottleneck and altered breeding patterns accompanying domestication. The second is a reduction of effective population size at loci linked to those under positive selection due to Hill-Robertson interference. An increase in slightly deleterious genetic variation could contribute to the prevalence of disease in modern dog breeds.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- genetic drift
- bottleneck
- selective constraint
- purifying selection
- domestication
- dog genome
- Biology
- Biologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database