Search: onr:"swepub:oai:DiVA.org:uu-106710" >
The Use of Lithium ...
-
Itsenko, OleksiyUppsala universitet,Institutionen för biokemi och organisk kemi
(author)
The Use of Lithium Amides in the Palladium-Mediated Synthesis of [Carbonyl-11C]Amides
- Article/chapterEnglish2007
Publisher, publication year, extent ...
-
Weinheim, Germany :Wiley,2007
-
printrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-106710
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-106710URI
-
https://doi.org/10.1002/ejoc.200700255DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
Weakly nucleophilic amines were converted into the corresponding lithium amides and used in either one- or two-pot palladium mediated-reactions with [11C]carbon monoxide and aryl iodides. It was found that palladium acyl complexes may be prepared in a separate step and have sufficient lifetime to be used in a subsequent reaction with a nucleophile. This two-pot procedure was used for the labelling synthesis of eleven amides (nine of which are analogues of WAY-100635, a 5-HT1A radioligand) from weakly nucleophilic amines. The results were compared to a direct one-pot procedure using lithium amides. Both approaches extend the scope of palladium-mediated carbonylation using [11C]carbon monoxide and aryl iodides allowing use of weakly nucleophilic amines.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Blom, ElisabethUppsala universitet,Institutionen för biokemi och organisk kemi,Bengt Långström(Swepub:uu)elblo622
(author)
-
Långström, BengtUppsala universitet,Institutionen för biokemi och organisk kemi(Swepub:uu)benglang
(author)
-
Kihlberg, Tor
(author)
-
Uppsala universitetInstitutionen för biokemi och organisk kemi
(creator_code:org_t)
Related titles
-
In:European Journal of Organic ChemistryWeinheim, Germany : Wiley2007:26, s. 4337-43421434-193X1099-0690
Internet link
Find in a library
To the university's database