Evidence for Time-dependent Maximum Increase ofFree Radical Damage and Eicosanoid Formation in theBrain as Related to Duration of Cardiac Arrest andCardio-pulmonary Resuscitation

Nozari, Ala (author): Uppsala universitet,Institutionen för kirurgiska vetenskaper

Rubertsson, Sten (author): Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation

Miclescu, Adriana (author): Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation

Wiklund, Lars (author): Uppsala universitet,Anestesiologi och intensivvård,cardiopulmonary resuscitation

(creator_code:org_t)

2009-07-07
2003
English.
In: Free radical research. - : Informa UK Limited. - 1071-5762 .- 1029-2470. ; 37:3, s. 251-256

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Abstract Subject headings

Recovery of neurological function in patients following cardiac arrest and cardiopulmonary resuscitation (CPR) is a complex event. Free radical induced oxidative stress is supposed to be involved in this process. We studied levels of 8-iso-PGF2alpha (indicating oxidative injury) and 15-keto-dihydro-PGF2alpha (indicating inflammatory response) in venous plasma obtained from the jugular bulb in a porcine model of experimental cardiopulmonary resuscitation (CPR) where 2, 5, 8, 10 or 12 min of ventricular fibrillation (VF) was followed by 5 or 8 min of closed-chest CPR. A significant increase of 8-iso-PGF2alpha was observed immediately following restoration of spontaneous circulation in all experiments of various duration of VF and CPR. No such increase was seen in a control group. When compared between the groups there was a duration-dependent maximum increase of 8-iso-PGF2alpha which was greatest in animals subjected to the longest period (VF12 min + CPR8 min) of no or low blood flow. In contrast, the greatest increase of 15-keto-dihydro-PGF2alpha was observed in the 13 min group (VF8 min + CPR5 min). Thus, a time-dependent cerebral oxidative injury occurs in conjunction which cardiac arrest and CPR.

By the author/editor: Basu, Samar; Liu, Xiaoli; Nozari, Ala; Rubertsson, Sten; Miclescu, Adrian ...; Wiklund, Lars

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Anesthesiology a ...

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