Search: onr:"swepub:oai:DiVA.org:uu-10718" >
Study of the role o...
Study of the role of functional variants of SLC22A4, RUNX1 and SUMO4 in systemic lupus erythematosus
-
Orozco, G. (author)
-
Sanchez, E. (author)
-
Gomez, L. M. (author)
-
show more...
-
Gonzalez-Gay, M. A. (author)
-
Lopez-Nevot, M. A. (author)
-
Torres, B. (author)
-
Ortego-Centeno, N. (author)
-
Jimenez-Alonso, J. (author)
-
de Ramon, E. (author)
-
Sanchez Roma¡n, J. (author)
-
Anaya, J. M. (author)
-
- Sturfelt, Gunnar (author)
- Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
-
- Gunnarsson, I. (author)
- Karolinska Institutet
-
Svennungsson, E. (author)
-
- Alarcón-Riquelme, Marta (author)
- Uppsala universitet,Institutionen för genetik och patologi
-
Gonzalez-Escribano, M. F. (author)
-
Martin, J. (author)
-
show less...
-
(creator_code:org_t)
- BMJ, 2006
- 2006
- English.
-
In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 65:6, s. 791-5
- Related links:
-
http://www.ncbi.nlm....
-
show more...
-
https://europepmc.or...
-
http://dx.doi.org/10...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://lup.lub.lu.s...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Functional polymorphisms of the solute carrier family 22, member 4 (SLC22A4), runt related transcription factor 1 (RUNX1) and small ubiquitin-like modifier 4 (SUMO4) genes have been shown to be associated with several autoimmune diseases. OBJECTIVE: To test the possible role of these variants in susceptibility to or severity of systemic lupus erythematosus (SLE), on the basis that common genetic bases are shared by autoimmune disorders. METHODS: 597 SLE patients and 987 healthy controls of white Spanish origin were studied. Two additional cohorts of 228 SLE patients from Sweden and 122 SLE patients from Colombia were included. A case-control association study was carried out with six single nucleotide polymorphisms (SNP) spanning the SLC22A4 gene, one SNP in RUNX1 gene, and one additional SNP in SUM04 gene. RESULTS: No significant differences were observed between SLE patients and healthy controls when comparing the distribution of the genotypes or alleles of any of the SLC22A4, RUNX1, or SUMO4 polymorphisms tested. Significant differences were found in the distribution of the SUMO4 genotypes and alleles among SLE patients with and without nephritis, but after multiple testing correction, the significance of the association was lost. The association of SUMO4 with nephritis could not be verified in two independent SLE cohorts from Sweden and Colombia. CONCLUSIONS: These results suggest that the SLC22A4, RUNX1, and SUMO4 polymorphisms analysed do not play a role in the susceptibility to or severity of SLE.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- Adult
- Alleles
- Case-Control Studies
- Chi-Square Distribution
- Core Binding Factor Alpha 2 Subunit/*genetics
- Female
- Genetic Predisposition to Disease
- Genotype
- Humans
- Lupus Erythematosus; Systemic/*genetics
- Male
- Middle Aged
- Odds Ratio
- Organic Cation Transport Proteins/*genetics
- Polymorphism; Genetic
- Small Ubiquitin-Related Modifier Proteins/*genetics
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Orozco, G.
-
Sanchez, E.
-
Gomez, L. M.
-
Gonzalez-Gay, M. ...
-
Lopez-Nevot, M. ...
-
Torres, B.
-
show more...
-
Ortego-Centeno, ...
-
Jimenez-Alonso, ...
-
de Ramon, E.
-
Sanchez Roma¡n, ...
-
Anaya, J. M.
-
Sturfelt, Gunnar
-
Gunnarsson, I.
-
Svennungsson, E.
-
Alarcón-Riquelme ...
-
Gonzalez-Escriba ...
-
Martin, J.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Annals of the Rh ...
- By the university
-
Uppsala University
-
Lund University
-
Karolinska Institutet