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- Duner, GunnarKTH,Yt- och korrosionsvetenskap,Department of Chemistry, KTH (author)
Signal Enhancement in Ligand-Receptor Interactions using Dynamic Polymers at Quartz Crystal Microbalance Surfaces
- Article/chapterEnglish2016
Publisher, publication year, extent ...
- 2016
- Royal Society of Chemistry (RSC),2016
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-107252
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107252URI
- https://doi.org/10.1039/c6an00735jDOI
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-190685URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20160815
- The potential for signal amplification on QCM sensors by use of in situ polymerized poly(acrylic acid) brushes has been studied. A biotin derivative was immobilized on these surfaces and the interaction with anti-biotin Fabs was evaluated. Interaction data was found to be specific for the studied binding events, and the level of non-specific binding was shown to be low. The surface was proven to be suitable for regeneration, of importance for biomolecular interaction analysis and repetitive immunoassays.For comparison, the same interaction system was tested using commercial sensor surfaces with carboxylated self-assembled monolayers. The poly(acrylic acid) surface showed a dramatic increase in signal response with more than ten times the signal of the carboxylated self-assembled monolayer surface. Thus, the present study shows that polymers can be successfully applied to amplify responses on QCM sensors, valuable for studies of interactions between receptors and low molecular weight compounds.
Subject headings and genre
- NATURVETENSKAP Kemi Polymerkemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Polymer Chemistry hsv//eng
- NATURVETENSKAP Kemi Organisk kemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Organic Chemistry hsv//eng
- dynamic chemistry
- quartz crystal microbalance
- iniferter
- photopolymerization
- biosensor
- interaction
- Polymer chemistry
- Polymerkemi
- Ytbioteknik
- Surface Biotechnology
Added entries (persons, corporate bodies, meetings, titles ...)
- Anderson, HenrikUppsala universitet,Fasta tillståndets elektronik,Attana AB,Thin Films Group(Swepub:uu)henan442 (author)
- Pei, ZhichaoAttana AB (author)
- Ingemarsson, BjörnAttana AB (author)
- Aastrup, TeodorAttana AB (author)
- Ramstrom, OlofKTH,Organisk kemi,Department of Chemistry, KTH(Swepub:kth)u1aj7snf (author)
- KTHYt- och korrosionsvetenskap (creator_code:org_t)
Related titles
- In:The Analyst: Royal Society of Chemistry (RSC)141:13, s. 3993-39960003-26541364-5528
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