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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03897naa a2200481 4500 | |
| 001 | oai:DiVA.org:uu-107272 | |
| 003 | SwePub | |
| 008 | 090803s2010 | |||||||||||000 ||eng| | |
| 009 | oai:prod.swepub.kib.ki.se:120918534 | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1072722 URI |
| 024 | 7 | a https://doi.org/10.1002/art.274172 DOI |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1209185342 URI |
| 040 | a (SwePub)uud (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Kristjánsdóttir, Helga,d 1966-u Uppsala universitet,Medicinsk genetik,Genetics of inflammatory diseases4 aut0 (Swepub:uu)helkr245 |
| 245 | 1 0 | a Lower expression levels of the programmed death 1 receptor on CD4+CD25+ T cells and correlation with the PD-1.3A genotype in patients with systemic lupus erythematosus |
| 264 | c 2010-02-22 | |
| 264 | 1 | b Wiley,c 2010 |
| 338 | a print2 rdacarrier | |
| 520 | a OBJECTIVE.: A genetic polymorphism, PD1.3A, in the PDCD1 gene encoding the co-inhibitory immunoreceptor PD-1, has been associated with SLE. The aim of the study was to assess PD-1 receptor expression in SLE patients, relatives and controls and correlate with PD-1.3A. METHODS.: Icelandic and Swedish SLE patients, relatives and controls were studied. PBMCs were stimulated with alphaCD3/CD28 and PD-1 expression analyzed by flow cytometry. PD-1.3A/G genotyping was performed by PCR-RFLP. RESULTS: I. PD-1 expression on PBMCs was induced after stimulation, by 2.1-fold in SLE patients, 3.1-fold in relatives and 5.1-fold in controls.II. The frequency of PD-1+ cells was significantly lower in SLE patients compared to relatives and controls. PD-1 expression on PD-1+ cells was significantly lower in SLE patients and relatives.III. PD-1 expression on CD4+CD25+ T cells was significantly lower in SLE patients and relatives.IV. PD-1 expression was significantly higher on CD25(high) compared to CD25(intermediate) and (low) cells.V. PD-1 expression on CD25(high) and CD25(intermediate) cells was significantly lower in SLE patients compared to controls.VI. PD-1 was expressed on both FoxP3- and FoxP3+ cells.VII. Lower PD-1 expression was significantly correlated with the PD-1.3A/G genotype. CONCLUSION.: The study demonstrates significantly lower PD-1 receptor expression in SLE patients and relatives and a significant correlation of lower PD-1 expression with the PD-1.3A allele. We conclude that PD-1.3A may be contributory to abnormalities in PD-1 receptor expression on CD4+CD25+ T-cells in SLE, providing support for an important role for the PD-1 pathway in SLE and possibly other autoimmune diseases. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
| 653 | a SLE | |
| 653 | a PD-1.3A | |
| 653 | a self-tolerance | |
| 653 | a Immunology | |
| 653 | a Immunologi | |
| 653 | a Immunologi | |
| 653 | a Immunology | |
| 700 | 1 | a Steinsson, Kristjan4 aut |
| 700 | 1 | a Gunnarsson, Ivau Karolinska Institutet4 aut |
| 700 | 1 | a Gröndal, Gerdur4 aut |
| 700 | 1 | a Erlendsson, Kristjan4 aut |
| 700 | 1 | a Alarcón-Riquelme, Marta E.u Uppsala universitet,Medicinsk genetik4 aut |
| 710 | 2 | a Uppsala universitetb Medicinsk genetik4 org |
| 773 | 0 | t Arthritis and Rheumatismd : Wileyg 62:6, s. 1702-1711q 62:6<1702-1711x 0004-3591x 1529-0131 |
| 856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/art.27417 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-107272 |
| 856 | 4 8 | u https://doi.org/10.1002/art.27417 |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:120918534 |
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