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The Impact of Nandr...
The Impact of Nandrolone Decanoate on Neuropeptidergic Mechanisms Related to Cognition, Aggression, Reward and Dependence
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- Magnusson, Kristina, 1976- (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Nyberg, Fred, Professor (thesis advisor)
- Uppsala universitet,Avdelningen för biologisk beroendeforskning
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- Hallberg, Mathias, Docent (thesis advisor)
- Uppsala universitet,Avdelningen för biologisk beroendeforskning
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- Spampinato, Santi Mario, Professor (opponent)
- University of Bologna
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(creator_code:org_t)
- ISBN 9789155475871
- Uppsala : Acta Universitatis Upsaliensis, 2009
- English 59 s.
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Series: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 1651-6192 ; 103
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Abstract
Subject headings
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- The abuse of anabolic androgenic steroids (AAS) is becoming increasingly common and may result in a range of physiological as well as psychological effects such as altered behavior in terms of increased aggression, cognitive dysfunction and addictive behavior. AAS comprise testosterone and its derivatives, of which nandrolone is one of the more common. Previous studies have shown nandrolone-induced effects in male rats on peptide levels within the Substance P (SP) system and the dynorphinergic system; these effects may be linked to some of the reported behavior alterations. The studies presented in this thesis aimed to investigate the mechanisms underlying these peptide alterations and also to further investigate neuropeptidergic effects attributed to nandrolone administration. The results display significant effects on the enzymatic conversion of SP and Dynorphin A into their bioactive metabolites SP(1-7) and Leu-enkephalin-Arg6, respectively, as a result of nandrolone treatment. More profound investigations on the dynorphinergic system displayed effects on the kappa opioid receptor density in various brain regions. There was also a significant increase in the expression of the gene transcript of prodynorphin in the hippocampus, a brain region associated with cognitive processes. In addition, impaired spatial learning and memory in the Morris water maze task following nandrolone administration was encountered. The results provide further understanding regarding neuropeptidergic mechanisms underlying AAS-induced behavioral effects.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Anabolic androgenic steroids
- Nandrolone decanoate
- Substance P
- Dynorphin A
- KOP receptor
- Prodynorphin
- Radioimmunoassay
- Autoradiography
- Morris water maze
- PCR
- Central nervous system
- Biological research on drug dependence
- Biologisk beroendeforskning
- Biological Research on Drug Dependence
- Biologisk beroendeforskning
Publication and Content Type
- vet (subject category)
- dok (subject category)
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