SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-108245"
 

Search: onr:"swepub:oai:DiVA.org:uu-108245" > Analysis of the DNA...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Zody, Michael,1968-Broad Institute (author)

Analysis of the DNA sequence and duplication history of human chromosome 15

  • Article/chapterEnglish2006

Publisher, publication year, extent ...

  • Springer Science and Business Media LLC,2006
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-108245
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108245URI
  • https://doi.org/10.1038/nature04601DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplication in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Garber, ManuelBroad Institute (author)
  • Sharpe, TedBroad Institute (author)
  • Young, SarahBroad Institute (author)
  • Rowen, LeeInstitute for Systems Biology (author)
  • O'Neill, KeithBroad Institute (author)
  • Whittaker, CharlesBroad Institute (author)
  • Kamal, MichaelBroad Institute (author)
  • Chang, JeanBroad Institute (author)
  • Cuomo, ChristinaBroad Institute (author)
  • Dewar, KenBroad Institute (author)
  • FitzGerald, MichaelBroad Institute (author)
  • Kodira, ChinnappaBroad Institute (author)
  • Madan, AnupInstitute for Systems Biology (author)
  • Qin, ShizhenInstitute for Systems Biology (author)
  • Yang, XiaopingBroad Institute (author)
  • Abbasi, NissaInstitute for Systems Biology (author)
  • Abouelleil, AmrBroad Institute (author)
  • Arachchi, HarindraBroad Institute (author)
  • Baradarani, LidaInstitute for Systems Biology (author)
  • Birditt, BrianInstitute for Systems Biology (author)
  • Bloom, ScottInstitute for Systems Biology (author)
  • Bloom, TobyBroad Institute (author)
  • Borowsky, MarkBroad Institute (author)
  • Burke, JeremyInstitute for Systems Biology (author)
  • Butler, JonathanBroad Institute (author)
  • Cook, AprilBroad Institute (author)
  • DeArellano, KurtBroad Institute (author)
  • DeCaprio, DavidBroad Institute (author)
  • Dorris, LesterBroad Institute (author)
  • Dors, MonicaInstitute for Systems Biology (author)
  • Eichler, EvanUniversity of Washington, Department of Genome Sciences (author)
  • Engels, ReinhardBroad Institute (author)
  • Fahey, JessicaInstitute for Systems Biology (author)
  • Fleetwood, PeterInstitute for Systems Biology (author)
  • Friedman, CynthiaFred Hutchinson Cancer Research Center, Division of Human Biology (author)
  • Gearin, GaryBroad Institute (author)
  • Hall, JenniferBroad Institute (author)
  • Hensley, GraceInstitute for Systems Biology (author)
  • Johnson, ErickaInstitute for Systems Biology (author)
  • Jones, CharlienBroad Institute (author)
  • Kamat, AshaBroad Institute (author)
  • Kaur, AmardeepInstitute for Systems Biology (author)
  • Locke, DevinUniversity of Washington, Department of Genome Sciences (author)
  • Madan, AnuradhaInstitute for Systems Biology (author)
  • Munson, GlenBroad Institute (author)
  • Jaffe, DavidBroad Institute (author)
  • Lui, AnnieBroad Institute (author)
  • Macdonald, PendexterBroad Institute (author)
  • Mauceli, EvanBroad Institute (author)
  • Naylor, JeromeBroad Institute (author)
  • Nesbitt, RyanInstitute for Systems Biology (author)
  • Nicol, RobertBroad Institute (author)
  • O'Leary, SinéadBroad Institute (author)
  • Ratcliffe, AmberInstitute for Systems Biology (author)
  • Rounsley, StevenBroad Institute (author)
  • She, XinweiUniversity of Washington, Department of Genome Sciences (author)
  • Sneddon, KatherineUniversity College London, Department of Biology,HUGO Gene Nomenclature Committee (author)
  • Stewart, SandraInstitute for Systems Biology (author)
  • Sougnez, CarrieBroad Institute (author)
  • Stone, SabrinaBroad Institute (author)
  • Topham, KerriBroad Institute (author)
  • Vincent, DascenaInstitute for Systems Biology (author)
  • Wang, ShunguangBroad Institute (author)
  • Zimmer, AndrewBroad Institute (author)
  • Birren, BruceBroad Institute (author)
  • Hood, LeroyInstitute for Systems Biology (author)
  • Lander, icBroad Institute (author)
  • Nusbaum, ChadBroad Institute (author)
  • Broad InstituteInstitute for Systems Biology (creator_code:org_t)

Related titles

  • In:Nature: Springer Science and Business Media LLC440:7084, s. 671-6750028-08361476-4687

Internet link

Find in a library

  • Nature (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view