DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

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Zody, Michael,1968-Broad Institute (author)

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage

Article/chapterEnglish2006

Publisher, publication year, extent ...

2006-04-01
Springer Science and Business Media LLC,2006
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-108247
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-108247URI
https://doi.org/10.1038/nature04689DOI

Supplementary language notes

Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

Notes

Chromosome 17 is unusual among the human chromosomes in many respects. It is the largest human autosome with orthology to only a single mouse chromosome, mapping entirely to the distal half of mouse chromosome 11. Chromosome 17 is rich in protein-coding genes, having the second highest gene density in the genome. It is also enriched in segmental duplications, ranking third in density among the autosomes. Here we report a finished sequence for human chromosome 17, as well as a structural comparison with the finished sequence for mouse chromosome 11, the first finished mouse chromosome. Comparison of the orthologous regions reveals striking differences. In contrast to the typical pattern seen in mammalian evolution, the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequence has been remarkably stable. Moreover, although the human sequence has a high density of segmental duplication, the mouse sequence has a very low density. Notably, these segmental duplications correspond closely to the sites of structural rearrangement, demonstrating a link between duplication and rearrangement. Examination of the main classes of duplicated segments provides insight into the dynamics underlying expansion of chromosome-specific, low-copy repeats in the human genome.

Subject headings and genre

NATURVETENSKAP Biologi Genetik hsv//swe
NATURAL SCIENCES Biological Sciences Genetics hsv//eng
Genetics
Genetik
Genetics
Genetik

Added entries (persons, corporate bodies, meetings, titles ...)

Garber, ManuelBroad Institute (author)
Adams, DavidThe Wellcome Trust Sanger Institute (author)
Sharpe, TedBroad Institute (author)
Harrow, JenniferThe Wellcome Trust Sanger Institute (author)
Lupski, JamesBaylor College of Medicine, Department of Molecular and Human Genetics (author)
Nicholson, ChristineThe Wellcome Trust Sanger Institute (author)
Searle, StevenThe Wellcome Trust Sanger Institute (author)
Wilming, LaurensThe Wellcome Trust Sanger Institute (author)
Young, SarahBroad Institute (author)
Abouelleil, AmrBroad Institute (author)
Allen, NicoleBroad Institute (author)
Bi, WeiminBaylor College of Medicine, Department of Molecular and Human Genetics (author)
Bloom, TobyBroad Institute (author)
Borowsky, MarkBroad Institute (author)
Bugalter, BorisBroad Institute (author)
Butler, JonathanBroad Institute (author)
Chang, JeanBroad Institute (author)
Chen, Chao-KungThe Wellcome Trust Sanger Institute (author)
Cook, AprilBroad Institute (author)
Corum, BenjaminBroad Institute (author)
Cuomo, ChristinaBroad Institute (author)
de Jong, PieterChildren's Hospital Oakland Research Institute,BACPAC Resources (author)
DeCaprio, DavidBroad Institute (author)
Dewar, KenBroad Institute (author)
FitzGerald, MichaelBroad Institute (author)
Gilbert, JamesThe Wellcome Trust Sanger Institute (author)
Gibson, RichardThe Wellcome Trust Sanger Institute (author)
Gnerre, SanteBroad Institute (author)
Goldstein, StevenUniversity of Wisconsin-Madison, Laboratory for Molecular and Computational Genomics (author)
Grafham, DarrenThe Wellcome Trust Sanger Institute (author)
Grocock, RussellThe Wellcome Trust Sanger Institute (author)
Hafez, NabilBroad Institute (author)
Hagopian, DanielBroad Institute (author)
Hart, ElizabethThe Wellcome Trust Sanger Institute (author)
Hosage Norman, CatherineBroad Institute (author)
Humphray, SeanThe Wellcome Trust Sanger Institute (author)
Jaffe, DavidBroad Institute (author)
Jones, MattThe Wellcome Trust Sanger Institute (author)
Kamal, MichaelBroad Institute (author)
Khodiyan, VarshaUniversity College London, Department of Biology,HUGO Gene Nomenclature Committee (author)
LaButti, KurtBroad Institute (author)
Laird, GavinThe Wellcome Trust Sanger Institute (author)
Lehoczky, JessicaBroad Institute (author)
Liu, XiaohongBroad Institute (author)
Lokyitsang, TashiBroad Institute (author)
Loveland, JaneThe Wellcome Trust Sanger Institute (author)
Lui, AnnieBroad Institute (author)
Macdonald, PendexterBroad Institute (author)
Major, JohnBroad Institute (author)
Matthews, LucyThe Wellcome Trust Sanger Institute (author)
Mauceli, EvanBroad Institute (author)
McCarroll, StevenBroad Institute (author)
Mihalev, AtanasBroad Institute (author)
Mudge, JonathanThe Wellcome Trust Sanger Institute (author)
Nguyen, CindyBroad Institute (author)
Nicol, RobertBroad Institute (author)
O'Leary, SinéadBroad Institute (author)
Osoegawa, KazutoyoChildren's Hospital Oakland Research Institute,BACPAC Resources (author)
Schwartz, DavidUniversity of Wisconsin-Madison, Laboratory for Molecular and Computational Genomics (author)
Shaw-Smith, CharlesThe Wellcome Trust Sanger Institute (author)
Stankiewicz, PawelBaylor College of Medicine, Department of Molecular and Human Genetics (author)
Steward, CharlesThe Wellcome Trust Sanger Institute (author)
Swarbreck, DavidThe Wellcome Trust Sanger Institute (author)
Venkataraman, VijayBroad Institute (author)
Whittaker, CharlesBroad Institute (author)
Yang, XiaopingBroad Institute (author)
Zimmer, AndrewBroad Institute (author)
Bradley, AllanThe Wellcome Trust Sanger Institute (author)
Hubbard, TimThe Wellcome Trust Sanger Institute (author)
Birren, BruceBroad Institute (author)
Rogers, JaneThe Wellcome Trust Sanger Institute (author)
Lander, EricBroad Institute (author)
Nusbaum, ChadBroad Institute (author)
Broad InstituteThe Wellcome Trust Sanger Institute (creator_code:org_t)

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In:Nature: Springer Science and Business Media LLC440:7087, s. 1045-10490028-08361476-4687

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By the author/editor: Zody, Michael, 1 ...; Garber, Manuel; Adams, David; Sharpe, Ted; Harrow, Jennifer; Lupski, James; show more...; Nicholson, Chris ...; Searle, Steven; Wilming, Laurens; Young, Sarah; Abouelleil, Amr; Allen, Nicole; Bi, Weimin; Bloom, Toby; Borowsky, Mark; Bugalter, Boris; Butler, Jonathan; Chang, Jean; Chen, Chao-Kung; Cook, April; Corum, Benjamin; Cuomo, Christina; de Jong, Pieter; DeCaprio, David; Dewar, Ken; FitzGerald, Mich ...; Gilbert, James; Gibson, Richard; Gnerre, Sante; Goldstein, Steve ...; Grafham, Darren; Grocock, Russell; Hafez, Nabil; Hagopian, Daniel; Hart, Elizabeth; Hosage Norman, C ...; Humphray, Sean; Jaffe, David; Jones, Matt; Kamal, Michael; Khodiyan, Varsha; LaButti, Kurt; Laird, Gavin; Lehoczky, Jessic ...; Liu, Xiaohong; Lokyitsang, Tash ...; Loveland, Jane; Lui, Annie; Macdonald, Pende ...; Major, John; Matthews, Lucy; Mauceli, Evan; McCarroll, Steve ...; Mihalev, Atanas; Mudge, Jonathan; Nguyen, Cindy; Nicol, Robert; O'Leary, Sinéad; Osoegawa, Kazuto ...; Schwartz, David; Shaw-Smith, Char ...; Stankiewicz, Paw ...; Steward, Charles; Swarbreck, David; Venkataraman, Vi ...; Whittaker, Charl ...; Yang, Xiaoping; Zimmer, Andrew; Bradley, Allan; Hubbard, Tim; Birren, Bruce; Rogers, Jane; Lander, Eric; Nusbaum, Chad; show less...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Genetics

Articles in the publication: Nature

By the university: Uppsala University

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