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Human papillomaviru...
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Fröberg, M.Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning, Västerås
(author)
Human papillomavirus 'reflex' testing as a screening method in cases of minor cytological abnormalities
- Article/chapterEnglish2008
Publisher, publication year, extent ...
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2008-08-05
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Springer Science and Business Media LLC,2008
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-109149
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-109149URI
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https://doi.org/10.1038/sj.bjc.6604504DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:117451199URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The aim was to evaluate human papillomavirus (HPV) 'reflex genotyping' in cases of minor cytological abnormalities detected in the gynaecological screening programme in Stockholm, Sweden. Liquid-based cytology samples showing minor cytological abnormalities were analysed using HPV genotyping (Linear Array, Roche diagnostics). Colposcopically directed cervical biopsies were obtained and the HPV test results were correlated with the histological results. In all, 63% (70/112) of the samples were high-risk (HR) HPV (HR-HPV) positive. A statistically significant correlation was found between high-grade cervical lesions and HR-HPV (P = 0.019), among which HPV 16, 18, and 31 were the most important. The negative predictive value of HR-HPV detection for histologically confirmed high-grade lesions was 100%. An age limit for HPV reflex testing may be motivated in cases of low-grade squamous intraepithelial neoplasia (LSIL), because of high HR-HPV prevalence among younger women. By using HPV reflex genotyping, additional extensive workup can safely be avoided in about 50% of all cases of atypical squamous cells of undetermined significance ( ASCUS) and LSIL among women > ;= 30 years. This screening strategy could potentially reduce the total abnormal cytology-reporting rate in the Swedish screening programme by about 1% and provide more accurately directed follow-up, guided by cytological appearance and HPV test results.
Subject headings and genre
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human papilloma virus (HPV)
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genotyping
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liquid-based cytology (LBC)
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atypical squamous cells of undetermined significance (ASCUS)
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low-grade squamous intraepithelial lesion (LSIL)
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cervical intraepithelial neoplasia (CIN)
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Johansson, B.Karolinska Institutet
(author)
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Hjerpe, A.Karolinska Institutet
(author)
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Andersson, S.Karolinska Institutet
(author)
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Uppsala universitetCentrum för klinisk forskning, Västerås
(creator_code:org_t)
Related titles
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In:British Journal of Cancer: Springer Science and Business Media LLC99:4, s. 563-5680007-09201532-1827
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