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Ropivacaine may hav...
Ropivacaine may have advantages compared to bupivacaine in porcine endotoxemic shock
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- Mutschler, Diana K. (author)
- Uppsala universitet,Anestesiologi och intensivvård
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Gustafsson, Urban (author)
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- Basu, Samar (author)
- Uppsala universitet,Institutionen för folkhälso- och vårdvetenskap,Oxidativ stress och inflammation
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- Larsson, Anders O. (author)
- Uppsala universitet,Klinisk kemi
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- Eriksson, Mats B. (author)
- Uppsala universitet,Anestesiologi och intensivvård
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(creator_code:org_t)
- 2006
- 2006
- English.
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In: Upsala Journal of Medical Sciences. - 0300-9734 .- 2000-1967. ; 111:2, s. 189-199
- Related links:
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https://urn.kb.se/re...
Abstract
Subject headings
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- Patients that undergo major abdominal surgery often receive epidural postoperative analgesia. Septic complications are frequently seen in this cohort. In a porcine model of endotoxemic shock, resembling human gram-negative septic shock, we evaluated the effects of two widely used local anaesthetics, bupivacaine and ropivacaine given intravenously. In the endotoxin-ropivacaine group mixed venous saturation and platelet count were higher as compared to endotoxemic controls. Mean arterial blood pressure and platelet count were higher in ropivacaine-endotoxin pigs than in bupivacaine-endotoxin ones. Bupivacaine augmented endotoxin-mediated decrease in left ventricular stroke work index. Ropivacaine displays pathophysiological advantages compared to bupivacaine in septic shock, which may be explained by improved tissue perfusion by ropivacaine.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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