Network organization of interstitial connective tissue cells in the human endolymphatic duct

The human endolymphatic duct (ED) and sac of the inner ear have been suggested to control endolymph volume and pressure. However, the physiological mechanisms for these processes remain obscure. We investigated the organization of the periductal interstitial connective tissue cells and extracellular matrix (ECM) in four freshly fixed human EDs by transmission electron microscopy and by immunohistochemistry. The unique surgical material allowed a greatly improved structural and epitopic preservation of tissue. Periductal connective tissue cells formed frequent intercellular contacts and focally occurring electron-dense contacts to ECM structures, creating a complex tissue network. The connective tissue cells also formed contacts with the basal lamina of the ED epithelium and the bone matrix, connecting the ED with the surrounding bone of the vestibular aqueduct. The interstitial connective tissue cells were non-endothelial and non-smooth muscle fibroblastoid cells. We suggest that the ED tissue network forms a functional mechanical entity that takes part in the control of inner ear fluid pressure and endolymph resorption.

Couloigner, Vincent (author)
Rubin, KristoferUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)krisrubi (author)
Rask-Andersen, HelgeUppsala universitet,Öron-, näs- och halssjukdomar(Swepub:uu)helgraan (author)
Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)

In:Journal of Histochemistry and Cytochemistry: SAGE Publications51:11, s. 1491-5000022-15541551-5044

By the author/editor: Hultgård-Ekwall, ...; Couloigner, Vinc ...; Rubin, Kristofer; Rask-Andersen, H ...

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.