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Hormone-replacement...
Hormone-replacement therapy influences gene expression profiles and is associated with breast-cancer prognosis : a cohort study
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- Hall, Per (author)
- Karolinska Institutet
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- Ploner, Alexander (author)
- Karolinska Institutet
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- Bjohle, Judith (author)
- Karolinska Institutet
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Huang, Fei (author)
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Lin, Chin-Yo (author)
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Liu, Edison T (author)
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Miller, Lance D (author)
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- Nordgren, Hans (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Pawitan, Yudi (author)
- Karolinska Institutet
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Shaw, Peter (author)
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- Skoog, Lambert (author)
- Karolinska Institutet
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- Smeds, Johanna (author)
- Karolinska Institutet
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- Wedren, Sara (author)
- Karolinska Institutet
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Ohd, John (author)
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- Bergh, Jonas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2006-06-30
- 2006
- English.
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In: BMC Medicine. - : Springer Science and Business Media LLC. - 1741-7015. ; 4, s. 16-
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https://bmcmedicine....
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Abstract
Subject headings
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- Background: Postmenopausal hormone-replacement therapy (HRT) increases breast-cancer risk. The influence of HRT on the biology of the primary tumor, however, is not well understood. Methods: We obtained breast-cancer gene expression profiles using Affymetrix human genome U133A arrays. We examined the relationship between HRT-regulated gene profiles, tumor characteristics, and recurrence-free survival in 72 postmenopausal women. Results: HRT use in patients with estrogen receptor ( ER) protein positive tumors (n = 72) was associated with an altered regulation of 276 genes. Expression profiles based on these genes clustered ER-positive tumors into two molecular subclasses, one of which was associated with HRT use and had significantly better recurrence free survival despite lower ER levels. A comparison with external data suggested that gene regulation in tumors associated with HRT was negatively correlated with gene regulation induced by short-term estrogen exposure, but positively correlated with the effect of tamoxifen. Conclusion: Our findings suggest that post-menopausal HRT use is associated with a distinct gene expression profile related to better recurrence-free survival and lower ER protein levels. Tentatively, HRT-associated gene expression in tumors resembles the effect of tamoxifen exposure on MCF-7 cells.
Keyword
- Breast Neoplasms/classification/diagnosis/*genetics/mortality/pathology
- Cell Line; Tumor
- Cohort Studies
- DNA Primers
- Disease-Free Survival
- Estrogen Replacement Therapy
- Female
- Gene Expression Profiling
- Humans
- Postmenopause
- Premenopause
- Receptors; Estrogen/*analysis
- Receptors; Progesterone/*analysis
- Survival Analysis
- Transcription; Genetic
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Hall, Per
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Ploner, Alexande ...
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Bjohle, Judith
-
Huang, Fei
-
Lin, Chin-Yo
-
Liu, Edison T
-
show more...
-
Miller, Lance D
-
Nordgren, Hans
-
Pawitan, Yudi
-
Shaw, Peter
-
Skoog, Lambert
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Smeds, Johanna
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Wedren, Sara
-
Ohd, John
-
Bergh, Jonas
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show less...
- Articles in the publication
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BMC Medicine
- By the university
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Uppsala University
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Karolinska Institutet