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GeneFinder: "in sil...
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Martinez Barrio, Alvaro,1977-Uppsala universitet,Centrum för bioinformatik,Bongcam-Rudloff
(author)
GeneFinder: "in silico" positional cloning of trait genes
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LIBRIS-ID:oai:DiVA.org:uu-112124
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112124URI
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Language:English
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Summary in:English
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Subject category:pop swepub-contenttype
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Subject category:ovr swepub-publicationtype
Notes
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Motivation: Positional cloning of trait genes is extremely laborious and the amount of information available on gene function in different organisms is increasing so rapidly that it is hard for a research group to collect all the relevant information from a number of data sources without performing a large number of manual and time consuming searches. Results: A web service application named GeneFinder was designed and implemented. It collects selected available information related to trait loci within a given chromosomal region that control a specific phenotype. The information contains details on gene function, disease conditions, tissue expression as well as predicted gene homologies in several other species. The information gathered is further ordered by a special-purpose ranking algorithm. A web interface to the GeneFinder web service was also developed where the results are presented in a ranked list easing its interpretation. We explain the design of the architecture, show how our web interface works, and finally test a candidate region. Availability: GeneFinder is publicly available and free to use. The web interface is available at http://www.genefinder.org/.
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Feifei, XuUppsala universitet,Institutionen för evolution, genomik och systematik,Molekylär evolution
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Lagercrantz, ErikDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff
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Bongcam-Rudloff, ErikDepartment of Animal Breeding and Genetics, Swedish University of Agricultural Sciences,Bongcam-Rudloff
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Uppsala universitetCentrum för bioinformatik
(creator_code:org_t)
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