onr:"swepub:oai:DiVA.org:uu-112916"
Search: onr:"swepub:oai:DiVA.org:uu-112916" > A novel powder samp...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Mahlin, DennyUppsala universitet,Institutionen för farmaci (author)
A novel powder sample holder for the determination of glass transition temperatures by DMA
- Article/chapterEnglish2009
Publisher, publication year, extent ...
- Elsevier BV,2009
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-112916
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-112916URI
- https://doi.org/10.1016/j.ijpharm.2008.12.039DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- The use of a new sample holder for dynamic mechanical analysis (DMA) as a means to characterise the Tg of powdered hydroxypropyl methyl cellulose (HPMC) has been investigated. A sample holder was constructed consisting of a rectangular stainless steel container and a lid engineered to fit exactly within the walls of the container when clamped within a TA instruments Q800 DMA in dual cantilever configuration. Physical mixtures of HPMC (E4M) and aluminium oxide powders were placed in the holder and subjected to oscillating strains (1 Hz, 10 Hz and 100 Hz) whilst heated at 3 degrees C/min. The storage and loss modulus signals showed a large reduction in the mechanical strength above 150 degrees C which was attributed to a glass transition. Optimal experimental parameters were determined using a design of experiment procedure and by analysing the frequency dependence of Tg in Arrhenius plots. The parameters were a clamping pressure of 62 kPa, a mass ratio of 0.2 HPMC in aluminium oxide, and a loading mass of either 120 mg or 180 mg. At 1 Hz, a Tg of 177+/-1.2 degrees C (n=6) for powdered HPMC was obtained. In conclusion, the new powder holder was capable of measuring the Tg of pharmaceutical powders and a simple optimization protocol was established, useful in further applications of the DMA powder holder.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- Amorphous powders
- Dynamic mechanical analysis (DMA)
- Amorphous content
- Glass transition
- HPMC
- Powder holder
- PHARMACY
- FARMACI
Added entries (persons, corporate bodies, meetings, titles ...)
- Wood, John (author)
- Hawkins, Nicholas (author)
- Mahey, Jas (author)
- Royall, Paul G (author)
- Uppsala universitetInstitutionen för farmaci (creator_code:org_t)
Related titles
- In:International Journal of Pharmaceutics: Elsevier BV371:1-2, s. 120-1250378-51731873-3476
Internet link
Find in a library
- International Journal of Pharmaceutics (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Mahlin, Denny
- Wood, John
- Hawkins, Nichola ...
- Mahey, Jas
- Royall, Paul G
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Pharmaceutical S ...
- Articles in the publication
- International Jo ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
