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Crystal structure c...
Crystal structure changes of gamma-cyclodextrin after the SEDS process in supercritical carbon dioxide affect the dissolution rate of complexed budesonide
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- Toropainen, Tarja (författare)
- University of Kuopio, Department of Pharmaceutical Chemistry
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- Heikkilä, Teemu (författare)
- University of Turku, Department of physics
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- Leppänen, Jukka (författare)
- University of Kuopio, Department of Pharmaceutical Chemistry
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- Matilainen, Laura (författare)
- University of Kuopio, Department of Pharmaceutical Chemistry
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- Velaga, Sitaram (författare)
- Luleå tekniska universitet,Uppsala universitet,Institutionen för farmaci,Medicinsk vetenskap
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- Jarho, Pekka (författare)
- University of Kuopio, Department of Pharmaceutical Chemistry
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- Carlfors, Johan (författare)
- Uppsala universitet,Institutionen för farmaci,University of Uppsala, Department of Pharmacy
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- Lehto, Vesa-Pekka (författare)
- University of Turku, Department of physics
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- Järvinen, Tomi (författare)
- University of Kuopio, Department of Pharmaceutical Chemistry
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- Järvinen, Kristiina (författare)
- University of Kuopio, Department of Pharmaceutics
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(creator_code:org_t)
- 2007-03-24
- 2007
- Engelska.
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Ingår i: Pharmaceutical research. - : Springer Science and Business Media LLC. - 0724-8741 .- 1573-904X. ; 24:6, s. 1058-1066
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Purpose. The present study describes the crystal structure changes of γ-cyclodextrin (γ-CD) during the solution enhanced dispersion by supercritical fluids (SEDS) process and its effect on dissolution behaviour of complexed budesonide. Materials and Methods. γ-CD solution (10 mg/ml in 50% ethanol) was pumped together with supercritical carbon dioxide through a coaxial nozzle with or without a model drug, budesonide (3.3 mg/ml). The processing conditions were 100 b and 40, 60 or 80°C. γ-CD powders were characterised before and after vacuum-drying (2-3 days at RT) with XRPD, SEM and NMR. Budesonide/γ-CD complexation was confirmed with DSC and XRPD. The dissolution behaviour of complexed budesonide was determined in aqueous solution (1% γ-CD, 37°C, 100 rpm). Results. During the SEDS process (100 b, 40 and 60°C), γ-CD and budesonide/γ-CD complexes crystallized in a tetragonal channel-type form. The vacuum-drying transformed crystalline γ-CD into amorphous form while the complexes underwent a tetragonal-to-hexagonal phase transition. The increase in the processing temperature decreased the crystallinity of γ-CD. At 80°C, amorphous γ-CD was obtained while the complexes crystallized in a hexagonal channel-type form. The dissolution behaviour of budesonide/γ-CD complexes was dependent on their crystal structure: the tetragonal form dissolved faster than the hexagonal form. Conclusions. The crystal structure of γ-CD and subsequently, the dissolution rate of complexed budesonide, can be modified with the processing conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- γ-cyclodextrin
- Amorphicity
- Budesonide
- Channel structure
- Complex
- Dissolution
- Hexagonal
- SEDS
- Supercritical fluids
- Tetragonal
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Toropainen, Tarj ...
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Heikkilä, Teemu
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Leppänen, Jukka
-
Matilainen, Laur ...
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Velaga, Sitaram
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Jarho, Pekka
-
visa fler...
-
Carlfors, Johan
-
Lehto, Vesa-Pekk ...
-
Järvinen, Tomi
-
Järvinen, Kristi ...
-
visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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och Farmaceutiska ve ...
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Pharmaceutical r ...
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Uppsala universitet
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Luleå tekniska universitet