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  • Gateva, VeselaImmunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-10-18
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-117767
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-117767URI
  • https://doi.org/10.1038/ng.468DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31020URI
  • https://lup.lub.lu.se/record/1504952URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119553608URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De två första författarna delar förstaförfattarskapet
  • Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent sample of 1,963 cases and 4,329 controls. This replication effort identified five new SLE susceptibility loci (P < 5 x 10(-8)): TNIP1 (odds ratio (OR) = 1.27), PRDM1 (OR = 1.20), JAZF1 (OR = 1.20), UHRF1BP1 (OR = 1.17) and IL10 (OR = 1.19). We identified 21 additional candidate loci with P< or = 1 x 10(-5). A candidate screen of alleles previously associated with other autoimmune diseases suggested five loci (P < 1 x 10(-3)) that may contribute to SLE: IFIH1, CFB, CLEC16A, IL12B and SH2B3. These results expand the number of confirmed and candidate SLE susceptibility loci and implicate several key immunologic pathways in SLE pathogenesis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Sandling, Johanna K.Uppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)josan062 (author)
  • Hom, GeoffImmunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Taylor, Kimberly E.Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA (author)
  • Chung, Sharon A.Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA (author)
  • Sun, XinImmunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Ortmann, WardImmunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Kosoy, RomanRowe Program in Genetics, University of California at Davis, Davis, California, USA (author)
  • Ferreira, Ricardo C.Immunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Nordmark, GunnelUppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)gunnnord (author)
  • Gunnarsson, IvaKarolinska Institutet (author)
  • Svenungsson, ElisabetKarolinska Institutet (author)
  • Padyukov, LeonidKarolinska Institutet (author)
  • Sturfelt, GunnarLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-gst (author)
  • Jönsen, AndreasLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-ajo (author)
  • Bengtsson, AndersLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-abe (author)
  • Rantapää-Dahlqvist, SolbrittUmeå universitet,Reumatologi(Swepub:umu)sora0001 (author)
  • Baechler, Emily C.Center for Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA (author)
  • Brown, Elizabeth E.University of Alabama at Birmingham, Birmingham, Alabama, USA (author)
  • Alarcón, Graciela S.University of Alabama at Birmingham, Birmingham, Alabama, USA (author)
  • Edberg, Jeffrey C.University of Alabama at Birmingham, Birmingham, Alabama, USA (author)
  • Ramsey-Goldman, RosalindNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA (author)
  • McGwin, GeraldUniversity of Alabama at Birmingham, Birmingham, Alabama, USA (author)
  • Reveille, John D.University of Texas–Houston Health Science Center, Houston, Texas, USA (author)
  • Vilá, Luis M.University of Puerto Rico Medical Science Campus, San Juan, Puerto Rico (author)
  • Kimberly, Robert P.University of Alabama at Birmingham, Birmingham, Alabama, USA (author)
  • Manzi, SusanUniversity of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA (author)
  • Petri, Michelle A.Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA (author)
  • Lee, AnnetteThe Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA (author)
  • Gregersen, Peter K.The Feinstein Institute for Medical Research, North Shore–Long Island Jewish Health System, Manhasset, New York, USA (author)
  • Seldin, Michael F.Rowe Program in Genetics, University of California at Davis, Davis, California, USA (author)
  • Rönnblom, LarsUppsala universitet,Institutionen för medicinska vetenskaper,Rheumatology, Systemic Autoimmmune Diseases,Section of Rheumatology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)larsronn (author)
  • Criswell, Lindsey A.Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California, San Francisco, California, USA (author)
  • Syvänen, Ann-ChristineUppsala universitet,Molekylär medicin,Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden(Swepub:uu)anncsyva (author)
  • Behrens, Timothy W.Immunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Graham, Robert R.Immunology Biomarkers Group, Genentech, South San Francisco, California, USA (author)
  • Immunology Biomarkers Group, Genentech, South San Francisco, California, USAMolekylär medicin (creator_code:org_t)

Related titles

  • In:Nature Genetics: Springer Science and Business Media LLC41:11, s. 1228-12331061-40361546-1718

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