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A new model for low...
A new model for low-dose food challenge in children with allergy to milk or egg.
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- Devenney, Irene (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Norrman, Gunilla (author)
- Linköpings universitet,Uppsala universitet,Centrum för klinisk forskning, Gävleborg,Pediatrik,Hälsouniversitetet
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- Oldaeus, Göran (author)
- Paediatric Clinic, County Hospital Ryhov, Jönköping, Sweden
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- Strömberg, Leif (author)
- Paediatric Clinic, Vrinnevi Hospital, Norrköping, Sweden
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- Fälth-Magnusson, Karin (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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(creator_code:org_t)
- Wiley, 2006
- 2006
- English.
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In: Acta Paediatr. - : Wiley. - 0803-5253 .- 1651-2227. ; 95:9, s. 1133-9
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http://urn.kb.se/res...
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https://doi.org/10.1...
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Abstract
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- Division of Paediatrics, Department of Molecular and Clinical Medicine, Faculty of Health Sciences, Linköping University, Linköping, and Paediatric Clinic, County Hospital Ryhov, Fonköping, Sweden. irene.devenney@lio.seBACKGROUND: Atopic eczema and food allergy are common in early childhood. Children seem to gradually develop tolerance to milk and egg, and it is a relief for families when their child can tolerate small amounts of these basic foods, even if larger doses may still cause symptoms. AIM: To develop a model for low-dose oral food challenge, facilitating re-/introduction of milk or egg. METHODS: In 39 children sensitized to milk and/or egg, we performed 52 challenges using a new standardized model for low-dose oral food challenge. The recipes were validated for blinding with sensorial tests. RESULTS: Four children challenged to milk had a positive challenge outcome. There were no significant differences with respect to family history, associated atopic manifestations, nutritional supply, eczema severity, or skin-prick test compared with the non-reacting children, but total and specific IgE values were significantly higher. All but two of the non-reacting children were able to introduce milk and egg into their diet without problems. CONCLUSION: We report recipes and a protocol to be used for standardized open and double-blind placebo-controlled low-dose food challenge in young children, enabling the introduction of small amounts of egg and milk into the diet during tolerance development.
Keyword
- Child; Preschool
- Cookery/*methods
- Double-Blind Method
- Egg Hypersensitivity/*therapy
- Female
- Humans
- Infant
- Male
- Milk Hypersensitivity/*therapy
- Prospective Studies
- Taste
- Treatment Outcome
- MEDICINE
Publication and Content Type
- ref (subject category)
- art (subject category)
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