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Risk Factors for St...
Risk Factors for Stroke in Adult Men : A Population-based Study
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- Wiberg, Bernice, 1956- (författare)
- Uppsala universitet,Geriatrik
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- Lind, Lars, Professor (preses)
- Uppsala universitet,Medicin
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- Sundström, Johan, Docent (preses)
- Uppsala universitet,Medicin
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- Zethelius, Björn, Docent (preses)
- Uppsala universitet,Geriatrik
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- Appelros, Peter, Docent (opponent)
- Institutionen för neurologi och geriatrik, Universitetssjukhuset i Örebro
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(creator_code:org_t)
- ISBN 9789155477530
- Uppsala : Acta Universitatis Upsaliensis, 2010
- Engelska 65 s.
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Serie: Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 1651-6206 ; 540
- Relaterad länk:
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- In the last decades our knowledge concerning cardiovascular risk factors has grown rapidly through results from longitudinal studies. However, despite new treatment, in Western countries coronary heart disease remains the leading cause of death and stroke is still the leading cause of severe disability. The studies reported in these papers examine the relationships between stroke/transient ischaemic attack (TIA) and a number of different factors measured on two different occasions in men born in Uppsala 1920-1924 and are epidemiological in their character. The findings indicate that in addition to already established risk factors, indices of an unhealthy dietary fat intake and high serum lipoprotein(a) are independent predictors of stroke/TIA. Among different glucometabolic variables a low insulin sensitivity index derived from the euglycaemic insulin clamp and proinsulin carries a high predictive value for later stroke, independently of diabetes. Moreover, cognitive test performance measured with Trail Making Test B at age 70 is a strong and independent predictor of brain infarction, indicating that the risk is already increased in the subclinical phase of milder cognitive dysfunction. Performance at a pre-stroke Trail Making Test is also of predictive value for mortality after first-ever stroke/TIA, but none of the studied pre-stroke variables or cognitive tests was found to be related to dependency after an event. In summary these studies provide further knowledge about predictors of stroke and of mortality after first-ever stroke. They also indicate the possible importance of new markers of risk, such as the level of lipoprotein(a), profile of fatty acids in the diet, low insulin sensitivity derived from clamp investigations, level of proinsulin, and cognitive performance measured with Trail Making Tests.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- risk factor
- stroke
- TIA
- lipoproteins
- fatty acids
- insulin resistance
- proinsulin
- clamp
- cognitive function
- epidemiology
- Trail Making Test
- stroke mortality
- dependency
- Geriatrics and medical gerontology
- Geriatrik och medicinsk gerontologi
- Medicinsk vetenskap
- Medical Science
Publikations- och innehållstyp
- vet (ämneskategori)
- dok (ämneskategori)
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