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Genotype-guided dos...
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van Schie, Rianne M. F.
(author)
Genotype-guided dosing of coumarin derivatives : the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design
- Article/chapterEnglish2009
Publisher, publication year, extent ...
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Future Medicine Ltd,2009
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-120547
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120547URI
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https://doi.org/10.2217/pgs.09.125DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The narrow therapeutic range and wide interpatient variability in dose requirement make anticoagulation response to coumarin derivatives unpredictable. As a result, patients require frequent monitoring to avert adverse effects and maintain therapeutic efficacy. Polymorphisms in VKORC1 and CYP2C9 jointly account for about 40% of the interindividual variability in dose requirements. To date, several pharmacogenetic-guided dosing algorithms for coumarin derivatives, predominately for warfarin, have been developed. However, the potential benefit of these dosing algorithms in terms of their safety and clinical utility has not been adequately investigated in randomized settings. The European Pharmacogenetics of Anticoagulant Therapy (EU-PACT) trial will assess, in a single-blinded and randomized controlled trial with a follow-up period of 3 months, the safety and clinical utility of genotype-guided dosing in daily practice for the three main coumarin derivatives used in Europe. The primary outcome measure is the percentage time in the therapeutic range for international normalized ratio. This report describes the design and protocol for the trial.
Subject headings and genre
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acenocoumarol
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CYP2C9
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dosing algorithm
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EU-PACT pharmacogenetics
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phenprocoumon
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randomized controlled trial
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VKORC1
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warfarin
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MEDICINE
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MEDICIN
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Clinical Pharmacology
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Klinisk farmakologi
Added entries (persons, corporate bodies, meetings, titles ...)
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Wadelius, MiaUppsala universitet,Klinisk farmakogenomik och osteoporos(Swepub:uu)miawadel
(author)
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Kamali, Farhad
(author)
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Daly, Ann K.
(author)
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Manolopoulos, Vangelis G.
(author)
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de Boer, Anthonius
(author)
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Barallon, Rita
(author)
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Verhoef, Talitha I.
(author)
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Kirchheiner, Julia
(author)
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Haschke-Becher, Elisabeth
(author)
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Briz, Montserrat
(author)
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Rosendaal, Frits R.
(author)
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Redekop, William K.
(author)
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Pirmohamed, Munir
(author)
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van der Zee, Anke-Hilse Maitland
(author)
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Uppsala universitetKlinisk farmakogenomik och osteoporos
(creator_code:org_t)
Related titles
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In:Pharmacogenomics (London): Future Medicine Ltd10:10, s. 1687-16951462-24161744-8042
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Barallon, Rita
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