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Systemic tocopherol...
Systemic tocopherols and F2-isoprostanes and the risk of Alzheimer's disease and dementia : a prospective population-based study
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- Sundelöf, Johan (author)
- Uppsala universitet,Geriatrik
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- Kilander, Lena (author)
- Uppsala universitet,Geriatrik
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- Helmersson, Johanna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Oxidativ stress och inflammation
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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- Rönnemaa, Elina (author)
- Uppsala universitet,Geriatrik
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- Degerman-Gunnarsson, Malin (author)
- Uppsala universitet,Geriatrik
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- Sjögren, Per (author)
- Uppsala universitet,Oxidativ stress och inflammation
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- Basun, Hans (author)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (author)
- Uppsala universitet,Geriatrik
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- Basu, Samar (author)
- Uppsala universitet,Oxidativ stress och inflammation
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Journal of Alzheimer's Disease. - 1387-2877 .- 1875-8908. ; 18:1, s. 71-78
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Oxidative stress in the brain is suggested to be involved in the pathophysiology of Alzheimer's disease (AD). In this study, serum alpha- and gamma-tocopherol, the two major systemic antioxidants, were analyzed at two examinations of the ULSAM-study, a longitudinal, community-based study of elderly men (age 70, n = 616 and age 77, n = 761). In addition, urinary F2-isoprostane levels, as markers of systemic oxidative stress, were analyzed at the age of 77 in this cohort (n = 679). Cox regression analyses were used to examine associations between serum alpha-, gamma-tocopherol and urinary F2-isoprostane levels and AD, any type of dementia (all-cause dementia) and non-AD dementia. On follow-up (median, 12.3 years), 40 subjects developed AD and 86 subjects developed all-cause dementia. Serum alpha- and gamma-tocopherol or urinary F2-isoprostane levels were not associated with the future risk of AD or dementia. In conclusion, systemic serum alpha- and gamma-tocopherol and urinary F2-isoprostane levels are not associated with the future risk of AD or dementia and do not seem to be useful predictors of clinical AD or dementia.
Keyword
- Alzheimer's disease
- dementia
- isoprostanes
- oxidative stress
- vitamins
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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