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The angiogenic grow...
The angiogenic growth factors HGF and VEGF in serum and plasma from neuroblastoma patients
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- Sköldenberg, Erik G. (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
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Jakobson, Åke (author)
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- Hedborg, Fredrik (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Kogner, Per (author)
- Karolinska Institutet
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- Christofferson, Rolf H. (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Barnkirurgi/Christofferson
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- Azarbayjani, Faranak (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: Anticancer Research. - 0250-7005 .- 1791-7530. ; 29:8, s. 3311-3319
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Abstract
Subject headings
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- AIM: To determine whether concentrations of the angiogenic growth factors hepatocyte growth factor (HGF) and vascular endothelial growth factor A (VEGF-A) correlate with clinical and genetic markers in samples taken at diagnosis in children with neuroblastoma (NB). PATIENTS AND METHODS: Heparin plasma (P-) and serum (S-) samples of healthy controls (n=73, mean age +/- SD 3.5+/-2.1; females/males: 23/50) and patients with NB (n=62; 2.2+/-1.8; 26/36) were collected between 1988 and 1999. Clinical data included age at diagnosis, gender, stage, outcome, amplification of the oncogene MYCN, loss of heterozygosity at the short arm of chromosome 1 (1p LOH) and ploidy. RESULTS: HGF and S-VEGF-A were elevated in NB as compared to controls (38/62 patients, p<0.0001 and p<0.05, Mann-Whitney U test). HGF concentrations were higher in high-stage (stage 3-4) as compared to low-stage (stage 1-2) disease (p<0.01). P-HGF was elevated in patients with 1p LOH (p<0.01), MYCN amplification (p<0.001) and di- or tetraploidy (p<0.001). S-HGF concentration was elevated in patients MYCN-amplified tumors only. Plasma and S-HGF concentrations were higher in the deceased group (p<0.05), but not P or S-VEGF-A. CONCLUSION: This study showed that concentrations of HGF and S-VEGF-A are elevated in patients with NB. Furthermore, HGF and S-VEGF-A concentrations correlate to higher stage disease and HGF correlates to genetic markers known to indicate a poor outcome. These observations imply that HGF and VEGF-A have biological roles in NB and suggest the possibility of interference with HGF or VEGF-A signaling as a therapeutic strategy.
Keyword
- Angiogenesis factor
- hepatocyte growth factor
- vascular endothelial growth factor
- tumor markers
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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