Search: onr:"swepub:oai:DiVA.org:uu-120858" >
Fibrinogen and hist...
Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia
-
- Kårehed, Karin (author)
- Karolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa
-
- Wikström, Anna-Karin (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
-
- Olsson, Anna-Karin (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
-
show more...
-
- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi
-
- Olovsson, Matts (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olvsson
-
- Åkerud, Helena (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson
-
show less...
-
(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
-
In: Acta Obstetricia et Gynecologica Scandinavica. - : Wiley. - 0001-6349 .- 1600-0412. ; 89:1, s. 131-139
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.3...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- OBJECTIVE: To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN: The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining. SETTING: Uppsala University Hospital, Uppsala. METHODS: Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry. RESULTS: Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001). CONCLUSIONS: HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.
Keyword
- Angiogenesis
- coagulation
- fibrinogen
- histidine-rich glycoprotein
- preeclampsia
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database