Fibrinogen and histidine-rich glycoprotein in early-onset preeclampsia

Kårehed, KarinKarolinska Institutet,Uppsala universitet,Institutionen för kvinnors och barns hälsa (author)

OBJECTIVE: To determine whether plasma levels of fibrinogen and the placental tissue distributions of fibrinogen and histidine-rich glycoprotein (HRG) differ between early- and late-onset preeclampsia. DESIGN: The study comprised 18 women with early-onset (gestational weeks 24-32) and 19 women with late-onset (gestational weeks 35-42) preeclampsia. As controls concerning the plasma levels of fibrinogen, we used samples from non-pregnant fertile women, healthy pregnant women at gestational weeks 24-32 and healthy pregnant women at gestational weeks 35-42. Placental samples from women with healthy pregnancies at gestational weeks 35-42 served as controls in the immunohistochemical staining. SETTING: Uppsala University Hospital, Uppsala. METHODS: Plasma fibrinogen levels were analyzed and the placental tissue expression of fibrinogen and HRG determined by immunohistochemistry. RESULTS: Plasma level of fibrinogen was increased in early-onset, but not late-onset, preeclampsia. Levels of fibrinogen were significantly lower, and that of HRG significantly higher, in placentas from women with early-onset preeclampsia as compared with control placentas (p = 0.01 and 0.001). CONCLUSIONS: HRG and fibrinogen might be involved in the hypercoagulability and the angiogenic imbalance seen in early-onset preeclampsia.

Wikström, Anna-KarinUppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson(Swepub:uu)annwi179 (author)
Olsson, Anna-KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)annaolss (author)
Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andla606 (author)
Olovsson, MattsUppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olvsson(Swepub:uu)mattolov (author)
Åkerud, HelenaUppsala universitet,Institutionen för kvinnors och barns hälsa,Obstetrisk forskning/Axelsson(Swepub:uu)helelars (author)
Uppsala universitetInstitutionen för kvinnors och barns hälsa (creator_code:org_t)

In:Acta Obstetricia et Gynecologica Scandinavica: Wiley89:1, s. 131-1390001-63491600-0412

By the author/editor: Kårehed, Karin; Wikström, Anna-K ...; Olsson, Anna-Kar ...; Larsson, Anders; Olovsson, Matts; Åkerud, Helena

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