onr:"swepub:oai:DiVA.org:uu-120864"
Search: onr:"swepub:oai:DiVA.org:uu-120864" > Signs of reduced an...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Bourlev, Vladimir,1947-Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson (author)
Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis
- Article/chapterEnglish2010
Publisher, publication year, extent ...
- Elsevier BV,2010
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-120864
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-120864URI
- https://doi.org/10.1016/j.fertnstert.2009.02.019DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- OBJECTIVE: To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers. DESIGN: Patients with endometriosis before and after surgery were compared with control patients. SETTING: University Hospital. PATIENT(S): Twenty-one healthy controls and 32 women with advanced endometriosis. INTERVENTION(S): In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy. MAIN OUTCOME MEASURE(S): Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery. RESULT(S): Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF. CONCLUSION(S): Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.
Subject headings and genre
- MEDICINE
- MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
- Ilyasova, Natalia,1971-Uppsala universitet,Obstetrik & gynekologi,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)natil371 (author)
- Adamyan, LeylaResearch Centre of Obstetrics, Gynecology and Perinatology, Russian Academy of the Medical Sciences, Moscow, Russia (author)
- Larsson, AndersUppsala universitet,Klinisk kemi(Swepub:uu)andla606 (author)
- Olovsson, Matts,1958-Uppsala universitet,Institutionen för kvinnors och barns hälsa,Klinisk och experimentell reproduktionsbiologi/Olovsson(Swepub:uu)mattolov (author)
- Uppsala universitetObstetrik & gynekologi (creator_code:org_t)
Related titles
- In:Fertility and Sterility: Elsevier BV94:1, s. 52-570015-02821556-5653
Internet link
Find in a library
- Fertility and Sterility (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Bourlev, Vladimi ...
- Ilyasova, Natali ...
- Adamyan, Leyla
- Larsson, Anders
- Olovsson, Matts, ...
- Articles in the publication
- Fertility and St ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
