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IGHV3-21 gene usage...
IGHV3-21 gene usage is associated with high TCL1 expression in chronic lymphocytic leukemia
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- Mansouri, Mahmoud R (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Sevov, Marie (author)
- Uppsala universitet,Medicinsk genetik och genomik
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- Åleskog, Anna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- Jondal, Mikael (author)
- Karolinska Institutet
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- Merup, Mats (author)
- Karolinska Institutet
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- Sundström, Christer (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Osorio, Lyda (author)
- Karolinska Institutet
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- Rosenquist, Richard (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
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In: European Journal of Haematology. - : Wiley. - 0902-4441 .- 1600-0609. ; 84:2, s. 109-116
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- T-cell leukemia/lymphoma protein 1 (TCL1) was recently shown to display an expression pattern in chronic lymphocytic leukemia (CLL) corresponding to molecular subtypes, where poor-risk patients demonstrated higher expression levels. Here, we examined the mRNA expression pattern of TCL1 in 144 patients with CLL, including 67 immunoglobulin heavy-chain variable (IGHV) mutated, 58 IGHV unmutated and 19 patients with IGHV3-21 usage. A higher TCL1 expression level was detected in patients with CLL with unmutated vs. mutated IGHV genes (P < 0.001), whereas no difference was demonstrated within the IGHV3-21 cohort (i.e., mutated vs. unmutated and stereotyped vs. non-stereotyped complementarity determining region 3). The IGHV3-21 subgroup displayed high TCL1 mRNA expression, differing significantly from other IGHV mutated cases (P < 0.001), although 11/19 had mutated IGHV genes. Furthermore, high TCL1 expression levels were associated with significantly shorter overall survival (P < 0.001). Altogether, we show that TCL1 mRNA expression may predict clinical outcome in CLL and that the IGHV3-21 subset, regardless of mutational status, displays high TCL1 expression.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Keyword
- Haematology
- Hematologi
Publication and Content Type
- ref (subject category)
- art (subject category)
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