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MHC2TA is associate...
MHC2TA is associated with differential MHC molecule expression and susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction
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- Swanberg, Maria (author)
- Karolinska Institutet
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- Lidman, Olle (author)
- Karolinska Institutet
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- Padyukov, Leonid (author)
- Karolinska Institutet
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- Eriksson, Per (author)
- Karolinska Institutet
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Åkesson, Eva (author)
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- Jagodic, Maja (author)
- Karolinska Institutet
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- Lobell, Anna (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Lobell / Kämpe
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- Khademi, Mohsen (author)
- Karolinska Institutet
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Börjesson, Ola (author)
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Lindgren, Cecilia M (author)
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- Lundman, Pia (author)
- Karolinska Institutet
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Brookes, Anthony J (author)
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- Kere, Juha (author)
- Karolinska Institutet
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- Luthman, Holger (author)
- Lund University,Lunds universitet,Genetik,Forskargrupper vid Lunds universitet,Genetics,Lund University Research Groups
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- Alfredsson, Lars (author)
- Karolinska Institutet
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- Hillert, Jan (author)
- Karolinska Institutet
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- Klareskog, Lars (author)
- Karolinska Institutet
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- Hamsten, Anders (author)
- Karolinska Institutet
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- Piehl, Fredrik (author)
- Karolinska Institutet
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- Olsson, Tomas (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2005-04-10
- 2005
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 37:5, s. 486-494
- Related links:
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http://dx.doi.org/10...
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Abstract
Subject headings
Close
- Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and, using a map over six inbred strains combined with gene sequencing and expression analysis, two conserved Mhc2ta haplotypes segregating with MHC class II levels. In humans, a -168A --> G polymorphism in the type III promoter of the MHC class II transactivator (MHC2TA) was associated with increased susceptibility to rheumatoid arthritis, multiple sclerosis and myocardial infarction, as well as lower expression of MHC2TA after stimulation of leukocytes with interferon-gamma. We conclude that polymorphisms in Mhc2ta and MHC2TA result in differential MHC molecule expression and are associated with susceptibility to common complex diseases with inflammatory components.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Swanberg, Maria
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Lidman, Olle
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Padyukov, Leonid
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Eriksson, Per
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Åkesson, Eva
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Jagodic, Maja
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show more...
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Lobell, Anna
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Khademi, Mohsen
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Börjesson, Ola
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Lindgren, Cecili ...
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Lundman, Pia
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Brookes, Anthony ...
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Kere, Juha
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Luthman, Holger
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Alfredsson, Lars
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Hillert, Jan
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Klareskog, Lars
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Hamsten, Anders
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Piehl, Fredrik
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Olsson, Tomas
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Uppsala University
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Lund University
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Karolinska Institutet