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Bone response to fr...
Bone response to free form fabricated hydroxyapatite and zirconia scaffolds : a transmission electron microscopy study in the human maxilla
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- Grandfield, Kathryn (author)
- Uppsala universitet,Tillämpad materialvetenskap,Materials in Medicine
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- Palmquist, Anders, 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Ericsson, Fredric (author)
- Uppsala universitet,Mikrosystemteknik
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- Malmström, Johan, 1975 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Emanuelsson, Lena, 1961 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Slotte, Christer, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Adolfsson, Erik (author)
- RISE,IVF
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- Botton, Gianluigi A. (author)
- Dept of Materials Science and Engineering, McMasters Unviersity, Hamilton, ON, Kanada
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- Thomsen, Peter, 1953 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för biomaterialvetenskap,Institute of Clinical Sciences, Department of Biomaterials
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- Engqvist, Håkan (author)
- Uppsala universitet,Tillämpad materialvetenskap
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(creator_code:org_t)
- 2010-02-11
- 2012
- English.
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In: Clinical Implant Dentistry and Related Research. - : Wiley. - 1523-0899 .- 1708-8208. ; 14:3, s. 461-469
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Abstract
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- Background: Understanding the interfacial reactions to synthetic bone regenerative scaffolds in vivo is fundamental for improving osseointegration and osteogenesis. Using transmission electron microscopy, it is possible to study the biological response of hydroxyapatite (HA) and zirconia (ZrO2) scaffolds at the nanometer scale.Purpose: In this study, the bone-bonding abilities of HA and ZrO2 scaffolds produced by free-form fabrication were evaluated in the human maxilla at 3 months and 7 months.Materials and Methods: HA and ZrO2 scaffolds (ø: 3 mm) were implanted in the human maxilla, removed with surrounding bone, embedded in resin, and sectioned. A novel focused ion beam (FIB) sample preparation technique enabled the production of thin lamellae for study by scanning transmission electron microscopy.Results: Interface regions were investigated using high-angle annular dark-field imaging and energy-dispersive X-ray spectroscopy analysis. Interfacial apatite layers of 80 nm and 50 nm thickness were noted in the 3- and 7-month HA samples, respectively, and bone growth was discovered in micropores up to 10 µm into the samples.Conclusions: The absence of an interfacial layer in the ZrO2 samples suggest the formation of a direct contact with bone, while HA, which bonds through an apatite layer, shows indications of resorption with increasing implantation time. This study demonstrates the potential of HA and ZrO2 scaffolds for use as bone regenerative materials.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Materialteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Materials Engineering (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
Keyword
- FIB
- free-form fabrication
- hydroxyapatite
- scaffolds
- TEM
- zirconia
- TECHNOLOGY
- TEKNIKVETENSKAP
- Teknisk fysik med inriktning mot mikrosystemteknik
- Engineering Science with specialization in Microsystems Technology
- Teknisk fysik med inriktning mot materialvetenskap
- Engineering Science with specialization in Materials Science
- osseointegration
- hydroxyapatite
- zirconia
- scaffolds
- free form fabrication
- FIB
- TEM
Publication and Content Type
- ref (subject category)
- art (subject category)
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Grandfield, Kath ...
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Palmquist, Ander ...
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Ericsson, Fredri ...
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Malmström, Johan ...
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Emanuelsson, Len ...
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Slotte, Christer ...
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Adolfsson, Erik
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Botton, Gianluig ...
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Thomsen, Peter, ...
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Engqvist, Håkan
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- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Materials Engine ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
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and Biomaterials Sci ...
- Articles in the publication
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Clinical Implant ...
- By the university
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Uppsala University
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RISE
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University of Gothenburg