Search: onr:"swepub:oai:DiVA.org:uu-122695" >
A hyaluronan-loadin...
-
Lindqvist, UllaUppsala universitet,Institutionen för medicinska vetenskaper,Reumatologi
(author)
A hyaluronan-loading test applied to patients with liver and joint diseases
- Article/chapterEnglish1992
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-122695
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122695URI
-
https://doi.org/10.1016/0009-8981(92)90050-ZDOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
The serum hyaluronan disappearance data, after an intravenous bolus injection of hyaluronan, were evaluated in terms of model-based parameters. The loading test was performed in 10 healthy persons (basal serum hyaluronan concentration, C0, 24.9 +/- 8.9 micrograms/l [mean +/- S.D.]), 6 patients with joint disease (62.3 +/- 41.1 micrograms/l) and 19 patients with liver disease (206 +/- 214 micrograms/l). The highest maximum Michaelis-Menten elimination rate (Vmax = 287 +/- 86 micrograms/min) was found in patients with joint disease, significantly higher than in healthy persons (Vmax = 179 +/- 16, P = 0.0015) and in patients with liver disease (Vmax = 149 +/- 59, P = 0.0002). C0 and Vmax were evaluated as discriminants for assessment of residual liver function. In patients with liver disease C0 correlated with liver function score (r = 0.875, P < 0.0001) and serum albumin concentration (r = -0.813, P < 0.0001). The Vmax parameter did not correlate with conventional liver function tests or with the liver score but a significantly negative correlation of Vmax with C0 was found in patients with liver disease. A combination of the C0 level and the Vmax parameter was found to discriminate between healthy persons, patients with joint disease and patients with liver disease and should be of benefit in separating patients, with or without elevated serum hyaluronan levels, into groups having increased influx or reduced elimination, respectively, of circulating hyaluronan.
Subject headings and genre
-
Elimination parameters
-
Healthy; Hyaluronan
-
Hyaluronate
-
Hyaluronic acid
-
Liver disease
-
Loading test
-
Rheumatoid arthritis
-
MEDICINE
-
MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
-
Groth, TorgnyUppsala universitet,Biomedicinsk informatik och teknik
(author)
-
Lööf, L.
(author)
-
Hellsing, K.
(author)
-
Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
-
In:Clinica Chimica Acta210:1-2, s. 119-1320009-89811873-3492
Internet link
Find in a library
To the university's database