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The sensitivity of ...
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Mårtensson, Gunnar
(author)
The sensitivity of hyaluronan analysis of pleural fluid from patients with malignant mesothelioma and a comparison of different methods
- Article/chapterEnglish1994
Publisher, publication year, extent ...
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-122710
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122710URI
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https://doi.org/10.1002/1097-0142(19940301)73:5<1406::AID-CNCR2820730515>3.0.CO;2-IDOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BACKGROUND: Hyaluronan may be used as a marker for malignant mesothelioma, thus indicating its mesodermal origin. METHODS: The sensitivity as a diagnostic test of three different methods for hyaluronan analyses of pleural fluid was examined in patients with biopsy-verified malignant pleural mesothelioma. RESULTS: A quantitative high-performance liquid-chromatography (HPLC) method was performed on fluids from 43 patients. Using a cutoff level of 100 mg/l, higher levels were noted in 30 (70%) patients, with a median value of 220 mg/l (mean, 560 mg/l; range, 20-6600 mg/l). An identical median value (220 mg/l) was obtained with a radioassay method when simultaneously performed on paired samples from 21 patients (correlation coefficient, 0.91). A qualitative precipitation test using 0.5% cetylpyridinium chloride combined with a quantitative viscosimetric method was significantly less sensitive (P < 0.01). CONCLUSION: Hyaluronan analyses is beneficial in distinguishing malignant mesothelioma if methods such as the evaluated HPLC or radioassay with a sensitivity of 70% toward mesothelioma are used and other known causes of elevated content are considered.
Subject headings and genre
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medical oncology
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mesothelioma
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pleural fluid
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hyaluronan
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sensitivity
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MEDICINE
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MEDICIN
Added entries (persons, corporate bodies, meetings, titles ...)
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Thylen, Anders
(author)
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Lindqvist, UllaUppsala universitet,Institutionen för medicinska vetenskaper,Reumatologi
(author)
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Hjerpe, Anders
(author)
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Uppsala universitetInstitutionen för medicinska vetenskaper
(creator_code:org_t)
Related titles
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In:Cancer73:5, s. 1406-14100008-543X1097-0142
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