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Age at onset of ano...
Age at onset of anorexia nervosa and breast cancer risk
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- Papadopoulos, Fotios C. (author)
- Uppsala universitet,Institutionen för neurovetenskap,psykiatri
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- Pantziaras, Ioannis (author)
- Uppsala universitet,Institutionen för neurovetenskap
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Lagiou, P (author)
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- Brandt, L (author)
- Karolinska Institutet
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- Ekselius, Lisa (author)
- Uppsala universitet,Institutionen för neurovetenskap,psykiatri
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- Ekbom, Anders (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2009
- 2009
- English.
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In: European Journal of Cancer Prevention. - 0959-8278 .- 1473-5709. ; 18:3, s. 207-211
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The objective of this study was to investigate breast cancer occurrence among women treated for anorexia nervosa (AN), with emphasis on age at the onset of this disorder. We conducted a register-based retrospective cohort with a total of 6009 women with at least one admission with an AN diagnosis (luring the period 1973-2003 in Sweden. During a mean follow-up of 13.4 years, information on 80057 women-years was generated. The standardized incidence ratio (SIR) - the ratio of observed-to-expected number of cases - was used as the measure of relative risk. Overall, 16 women developed breast cancer versus 25.5 expected cases [SIR: 0.6, 95% confidence interval (CI): 0.4-0.9]. Among women who were first admitted for AN between the age of 10 and 24 years, four developed breast cancer versus 11.3 expected (SIR: 0.4, 95% CI: 0.1-0.9). In this group of women with early onset AN, only one parous woman developed breast cancer versus 6.3 expected (SIR: 0.2,95% CI: 0-0.9). Among women first hospitalized for AN between the age of 25 and 40 years, 12 developed breast cancer, whereas the expected number was 14.2, a nonsignificant deficit Our results suggest that early onset AN may play an important role in the development of breast cancer, possibly because of the extreme restriction of energy intake at a crucial period for mammary gland development. Late onset AN is likely to play a relatively less important role.
Keyword
- anorexia nervosa
- breast cancer
- cohort study
- register study
- Sweden
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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