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  • Lu, R (author)

Genetic associations of LYN with systemic lupus erythematosus

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-04-16
  • Springer Science and Business Media LLC,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-122923
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-122923URI
  • https://doi.org/10.1038/gene.2009.19DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119087330URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We targeted LYN, a src-tyosine kinase involved in B-cell activation, in case-control association studies using populations of European-American, African-American and Korean subjects. Our combined European-derived population, consisting of 2463 independent cases and 3131 unrelated controls, shows significant association with rs6983130 in a female-only analysis with 2254 cases and 2228 controls (P=1.1 x 10(-4), odds ratio (OR)=0.81 (95% confidence interval: 0.73-0.90)). This single nucleotide polymorphism (SNP) is located in the 5' untranslated region within the first intron near the transcription initiation site of LYN. In addition, SNPs upstream of the first exon also show weak and sporadic association in subsets of the total European-American population. Multivariate logistic regression analysis implicates rs6983130 as a protective factor for systemic lupus erythematosus (SLE) susceptibility when anti-dsDNA, anti-chromatin, anti-52 kDa Ro or anti-Sm autoantibody status were used as covariates. Subset analysis of the European-American female cases by American College of Rheumatology classification criteria shows a reduction in the risk of hematological disorder with rs6983130 compared with cases without hematological disorders (P=1.5 x 10(-3), OR=0.75 (95% CI: 0.62-0.89)). None of the 90 SNPs tested show significant association with SLE in the African American or Korean populations. These results support an association of LYN with European-derived individuals with SLE, especially within autoantibody or clinical subsets.

Subject headings and genre

  • systemic lupus erythematosus
  • association
  • LYN
  • SNP
  • MEDICINE
  • MEDICIN

Added entries (persons, corporate bodies, meetings, titles ...)

  • Vidal, G S (author)
  • Kelly, J A (author)
  • Delgado-Vega, Angelica MUppsala universitet,Institutionen för genetik och patologi (author)
  • Howard, X K (author)
  • Macwana, S R (author)
  • Dominguez, N (author)
  • Klein, W (author)
  • Burrell, C (author)
  • Harley, I T (author)
  • Kaufman, K M (author)
  • Bruner, G R (author)
  • Moser, K L (author)
  • Gaffney, P M (author)
  • Gilkeson, G S (author)
  • Wakeland, E K (author)
  • Li, Q-Z (author)
  • Langefeld, C D (author)
  • Marion, M C (author)
  • Divers, J (author)
  • Alarcón, G S (author)
  • Brown, E E (author)
  • Kimberly, R P (author)
  • Edberg, J C (author)
  • Ramsey-Goldman, R (author)
  • Reveille, J D (author)
  • McGwin, G (author)
  • Vilá, L M (author)
  • Petri, M A (author)
  • Bae, S-C (author)
  • Cho, S-K (author)
  • Bang, S-Y (author)
  • Kim, I (author)
  • Choi, C-B (author)
  • Martin, J (author)
  • Vyse, T J (author)
  • Merrill, J T (author)
  • Harley, J B (author)
  • Alarcón-Riquelme, Marta EUppsala universitet,Institutionen för genetik och patologi(Swepub:uu)martaala (author)
  • Nath, S K (author)
  • James, J A (author)
  • Guthridge, J M (author)
  • Uppsala universitetInstitutionen för genetik och patologi (creator_code:org_t)

Related titles

  • In:Genes and Immunity: Springer Science and Business Media LLC10:5, s. 397-4031466-48791476-5470

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