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Sexually dimorphic ...
Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease : New data and meta-analysis
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Fukumoto, Noriko (author)
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Fujii, Takashi (author)
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Combarros, Onofre (author)
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Kamboh, M Ilyas (author)
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Tsai, Shin-Jen (author)
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Matsushita, Sachio (author)
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Nacmias, Benedetta (author)
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Comings, David E (author)
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Arboleda, Humberto (author)
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik
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Hyman, Bradley T (author)
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Akatsu, Hiroyasu (author)
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Grupe, Andrew (author)
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Nishimura, Agnes Lumi (author)
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Zatz, Mayana (author)
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Mattila, Kari M (author)
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Rinne, Juha (author)
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Goto, Yu-ichi (author)
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Asada, Takashi (author)
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Nakamura, Shun (author)
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Kunugi, Hiroshi (author)
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(creator_code:org_t)
- Wiley, 2010
- 2010
- English.
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In: American journal of medical genetics. Part B, Neuropsychiatric genetics. - : Wiley. - 1552-4841 .- 1552-485X. ; 153B:1, s. 235-242
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Conflicting results have been reported as to whether genetic variations (Val66Met and C270T) of the brain-derived neurotrophic factor gene (BDNF) confer susceptibility to Alzheimer's disease (AD). We genotyped these polymorphisms in a Japanese sample of 657 patients with AD and 525 controls, and obtained weak evidence of association for Val66Met (P = 0.063), but not for C270T. After stratification by sex, we found a significant allelic association between Val66Met and AD in women (P = 0.017), but not in men. To confirm these observations, we collected genotyping data for each sex from 16 research centers worldwide (4,711 patients and 4,537 controls in total). The meta-analysis revealed that there was a clear sex difference in the allelic association; the Met66 allele confers susceptibility to AD in women (odds ratio = 1.14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD.
Keyword
- Alzheimer's disease (AD)
- brain-derived neurotrophic factor (BDNF)
- meta-analysis
- polymorphism
- sex difference
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Fukumoto, Noriko
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Fujii, Takashi
-
Combarros, Onofr ...
-
Kamboh, M Ilyas
-
Tsai, Shin-Jen
-
Matsushita, Sach ...
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show more...
-
Nacmias, Benedet ...
-
Comings, David E
-
Arboleda, Humber ...
-
Ingelsson, Marti ...
-
Hyman, Bradley T
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Akatsu, Hiroyasu
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Grupe, Andrew
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Nishimura, Agnes ...
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Zatz, Mayana
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Mattila, Kari M
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Rinne, Juha
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Goto, Yu-ichi
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Asada, Takashi
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Nakamura, Shun
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Kunugi, Hiroshi
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show less...
- Articles in the publication
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American journal ...
- By the university
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Uppsala University