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Endothelial functio...
Endothelial function in patients with polycystic ovary syndrome : a long-term follow-up study
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- Hudecova, Miriam, 1971- (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Holte, Jan (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Olovsson, Matts (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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- Lind, Lars (author)
- Uppsala universitet,Medicin
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- Poromaa, Inger Sundström (author)
- Uppsala universitet,Institutionen för kvinnors och barns hälsa
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(creator_code:org_t)
- Elsevier BV, 2010
- 2010
- English.
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In: Fertility and Sterility. - : Elsevier BV. - 0015-0282 .- 1556-5653. ; 94:7, s. 2654-2658
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Objective: To investigate pulse wave reflection and endothelial-dependent vasodilatation (EDV) in PCOS patients and age-matched healthy controls. Design: Long-term follow-up study. Setting: Department of Women’s and Children’s Health, Uppsala University, Sweden. Patient(s): Sixty-seven PCOS patients with a mean age of 43.3 years at the follow-up investigation and 66 age-matched controls. Intervention: Aplanation tonometry before and after b-2 receptor agonist (terbutaline) challenge. Main outcome measure(s): Baseline augmentation index (AI) aorta, baseline AI-radial, and change in AI-radial following terbutaline administration as a measure of EDV. Result(s): There was no difference in baseline AI-aorta between PCOS patients and control subjects. Change in AI-radial following terbutaline administration was less pronounced in PCOS patients in comparison to control subjects. This difference remained when adjusted for use of combined oral contraceptives/hormone replacement therapy and postmenopausal status but not after adjustment for BMI. Conclusion(s): Middle-aged PCOS patients display signs of endothelial dysfunction in comparison to age-matched controls, but this is largely due to the increased prevalence of independent risk factors for cardiovascular disease found in this group.
Keyword
- polycystic ovary syndrome
- endothelial function
- endothelial-dependent vasodilation
- long-term
- follow-up
- MEDICINE
- MEDICIN
- Obstetrik och gynekologi
- Obstetrics and Gynaecology
Publication and Content Type
- ref (subject category)
- art (subject category)
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