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VEGF receptor 2/-3 ...
VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
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- Nilsson, Ingrid (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Bahram, Fuad (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Li, Xiujuan (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Gualandi, Laura (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Koch, Sina (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Jarvius, Malin (author)
- Uppsala universitet,Institutionen för genetik och patologi
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- Söderberg, Ola (author)
- Uppsala universitet,Institutionen för genetik och patologi
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Anisimov, Andrey (author)
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Kholová, Ivana (author)
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Pytowski, Bronislaw (author)
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Baldwin, Megan (author)
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Ylä-Herttuala, Seppo (author)
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Alitalo, Kari (author)
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- Kreuger, Johan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Claesson-Welsh, Lena (author)
- Uppsala universitet,Institutionen för genetik och patologi
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(creator_code:org_t)
- 2010-03-11
- 2010
- English.
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In: EMBO Journal. - : Wiley. - 0261-4189 .- 1460-2075. ; 29:8, s. 1377-1388
- Related links:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The vascular endothelial growth factors VEGFA and VEGFC are crucial regulators of vascular development. They exert their effects by dimerization and activation of the cognate receptors VEGFR2 and VEGFR3. Here, we have used in situ proximity ligation to detect receptor complexes in intact endothelial cells. We show that both VEGFA and VEGFC potently induce formation of VEGFR2/-3 heterodimers. Receptor heterodimers were found in both developing blood vessels and immature lymphatic structures in embryoid bodies. We present evidence that heterodimers frequently localize to tip cell filopodia. Interestingly, in the presence of VEGFC, heterodimers were enriched in the leading tip cells as compared with trailing stalk cells of growing sprouts. Neutralization of VEGFR3 to prevent heterodimer formation in response to VEGFA decreased the extent of angiogenic sprouting. We conclude that VEGFR2/-3 heterodimers on angiogenic sprouts induced by VEGFA or VEGFC may serve to positively regulate angiogenic sprouting.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Molecular medicine (genetics and pathology)
- Molekylär medicin (genetik och patologi)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nilsson, Ingrid
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Bahram, Fuad
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Li, Xiujuan
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Gualandi, Laura
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Koch, Sina
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Jarvius, Malin
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show more...
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Söderberg, Ola
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Anisimov, Andrey
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Kholová, Ivana
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Pytowski, Bronis ...
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Baldwin, Megan
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Ylä-Herttuala, S ...
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Alitalo, Kari
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Kreuger, Johan
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Claesson-Welsh, ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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EMBO Journal
- By the university
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Uppsala University