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Steroid biosynthesi...
Steroid biosynthesis within the frog brain : a model of neuroendocrine regulation
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Do Rego, Jean-Luc (author)
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Seong, Jae Young (author)
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Burel, Delphine (author)
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Luu-The, Van (author)
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- Larhammar, Dan (author)
- Uppsala universitet,Farmakologi,Larhammar
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Tsutsui, Kazuyoshi (author)
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Pelletier, Georges (author)
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Tonon, Marie-Christine (author)
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Vaudry, Hubert (author)
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(creator_code:org_t)
- 2009-04-27
- 2009
- English.
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In: Annals of the New York Academy of Sciences. - : Wiley. - 0077-8923 .- 1749-6632. ; 1163, s. 83-92
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [(3)H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by gamma-aminobutyric acid (GABA), acting through GABA(A) receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.
Keyword
- eurosteroids
- brain
- neuropeptides
- neurotransmitters
- amphibians
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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