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  • Askling, JohanKarolinska Institutet (author)

Cancer risk in patients with rheumatoid arthritis treated with anti-tumor necrosis factor alpha therapies : does the risk change with the time since start of treatment?

  • Article/chapterEnglish2009

Publisher, publication year, extent ...

  • 2009-10-29
  • Wiley,2009
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-123999
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-123999URI
  • https://doi.org/10.1002/art.24941DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-30993URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-52389URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:119595041URI
  • https://lup.lub.lu.se/record/1519632URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE:To determine the short-term and medium-term risks of cancer in patients receiving anti-tumor necrosis factor alpha (anti-TNFalpha) therapies that have proven effective in the treatment of chronic inflammatory conditions.METHODS:By linking together data from the Swedish Biologics Register, Swedish registers of RA, and the Swedish Cancer Register, we identified and analyzed for cancer occurrence a national cohort of 6,366 patients with RA who first started anti-TNF therapy between January 1999 and July 2006. As comparators, we used a national biologics-naive RA cohort (n = 61,160), a cohort of RA patients newly starting methotrexate (n = 5,989), a cohort of RA patients newly starting disease-modifying antirheumatic drug combination therapy (n = 1,838), and the general population of Sweden. Relative risks (RRs) were estimated using Cox regression analyses, examining overall RR as well as RR by time since the first start of anti-TNF therapy, by the duration of active anti-TNF therapy, and by the anti-TNF agent received.RESULTS:During 25,693 person-years of followup in 6,366 patients newly starting anti-TNF, 240 first cancers occurred, yielding an RR of 1.00 (95% confidence interval 0.86-1.15) versus the biologics-naive RA cohort, and similar RRs versus the other 2 RA comparators. RRs did not increase with increasing time since the start of anti-TNF therapy, nor with the cumulative duration of active anti-TNF therapy. During the first year following the first treatment start, but not thereafter, dissimilar cancer risks for adalimumab, etanercept, and infliximab were observed.CONCLUSION:During the first 6 years after the start of anti-TNF therapy in routine care, no overall elevation of cancer risk and no increase with followup time were observed.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • van Vollenhoven, Ronald F.Karolinska Institutet (author)
  • Granath, FredrikKarolinska Institutet (author)
  • Raaschou, PaulineKarolinska Institutet (author)
  • Fored, C. MichaelKarolinska Institutet (author)
  • Baecklund, EvaUppsala universitet,Reumatologi,Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)evaba786 (author)
  • Dackhammar, ChristinaSahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Feltelius, NilsKarolinska University Hospital at Solna and Karolinska Institutet, Stockholm, Sweden, and Medical Products Agency, Uppsala, Sweden,Medical Products Agency, Uppsala, Sweden (author)
  • Cöster, LarsÖstergötlands Läns Landsting,Linköpings universitet,Reumatologi,Hälsouniversitetet,Länskliniken för Reumatologi i Östergötland(Swepub:liu)larco79 (author)
  • Geborek, PierreLund University Hospital, Lund, Sweden (author)
  • Jacobsson, LennartLund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups(Swepub:lu)orto-lja (author)
  • Lindblad, StaffanKarolinska Institutet (author)
  • Rantapää-Dahlqvist, Solbritt,1947-Umeå universitet,Reumatologi,Norrland University Hospital, Umeå, Sweden(Swepub:umu)sora0001 (author)
  • Saxne, ToreLund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)reum-tsa (author)
  • Klareskog, LarsKarolinska Institutet (author)
  • Karolinska InstitutetReumatologi (creator_code:org_t)

Related titles

  • In:Arthritis and Rheumatism: Wiley60:11, s. 3180-31890004-35911529-0131

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